Comparative Study Of Patients With Chronic Hepatitis C Virus Infection Due To Genotypes 1 And 3 Referred For Treatment In Southeast Brazil.

dc.creatorVigani, Aline G
dc.creatorPavan, Maria H
dc.creatorTozzo, Raquel
dc.creatorGonçales, Eduardo S L
dc.creatorFeltrin, Adriana
dc.creatorFais, Viviane C
dc.creatorLazarini, Maria S K
dc.creatorGonçales, Neiva S L
dc.creatorGonçales, Fernando L
dc.date2008
dc.date2015-11-27T13:13:22Z
dc.date2015-11-27T13:13:22Z
dc.date.accessioned2018-03-29T01:07:50Z
dc.date.available2018-03-29T01:07:50Z
dc.identifierBmc Infectious Diseases. v. 8, p. 164, 2008.
dc.identifier1471-2334
dc.identifier10.1186/1471-2334-8-164
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19055835
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198063
dc.identifier19055835
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298296
dc.descriptionThe progression of liver disease in patients with chronic hepatitis C virus (HCV) infection is influenced by host and viral factors. Distinct clinical outcomes in patients infected with different HCV genotypes have been described in the literature. However, the association between specific HCV genotype and clinical outcome remains unclear. We set out to study the natural history of HCV genotype 1 and 3 infections in Campinas, São Paulo state, Brazil, focusing on epidemiological, clinical, biochemical, and histological characteristics. Patients with HCV infection referred for treatment between January 2003 and December 2006 were included in this study. We collected epidemiological, clinical, and laboratorial data using standard forms. A total of 283 patients were included; genotype 1 was identified in 163 (57.6%) patients, genotype 3 in 112 (39.6%), genotype 2 in 7 (2.5%), and genotype 4 in 1 (0.35%). Patients with genotype 2 and 4 were excluded from analysis. Multivariate analysis showed that intravenous energetic drug, positive cryoglobulin, and cirrhosis were independently and significantly associated with HCV genotype 3 (p < 0.05). Genotype 3 currently seems to be associated with intravenous energetic drug, high frequency of cryoglobulinemia, and advanced liver disease in our region. Understanding the distribution of the different HCV genotypes can elucidate transmission of HCV and support optimal prevention strategies.
dc.description8
dc.description164
dc.languageeng
dc.relationBmc Infectious Diseases
dc.relationBMC Infect. Dis.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectBrazil
dc.subjectFemale
dc.subjectGenotype
dc.subjectHepacivirus
dc.subjectHepatitis C, Chronic
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.titleComparative Study Of Patients With Chronic Hepatitis C Virus Infection Due To Genotypes 1 And 3 Referred For Treatment In Southeast Brazil.
dc.typeArtículos de revistas


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