A Genome Survey Of Moniliophthora Perniciosa Gives New Insights Into Witches' Broom Disease Of Cacao.

dc.creatorMondego, Jorge M C
dc.creatorCarazzolle, Marcelo F
dc.creatorCosta, Gustavo G L
dc.creatorFormighieri, Eduardo F
dc.creatorParizzi, Lucas P
dc.creatorRincones, Johana
dc.creatorCotomacci, Carolina
dc.creatorCarraro, Dirce M
dc.creatorCunha, Anderson F
dc.creatorCarrer, Helaine
dc.creatorVidal, Ramon O
dc.creatorEstrela, Raíssa C
dc.creatorGarcía, Odalys
dc.creatorThomazella, Daniela P T
dc.creatorde Oliveira, Bruno V
dc.creatorPires, Acássia Bl
dc.creatorRio, Maria Carolina S
dc.creatorAraújo, Marcos Renato R
dc.creatorde Moraes, Marcos H
dc.creatorCastro, Luis A B
dc.creatorGramacho, Karina P
dc.creatorGonçalves, Marilda S
dc.creatorNeto, José P Moura
dc.creatorNeto, Aristóteles Góes
dc.creatorBarbosa, Luciana V
dc.creatorGuiltinan, Mark J
dc.creatorBailey, Bryan A
dc.creatorMeinhardt, Lyndel W
dc.creatorCascardo, Julio Cm
dc.creatorPereira, Gonçalo A G
dc.date2008
dc.date2015-11-27T13:13:20Z
dc.date2015-11-27T13:13:20Z
dc.date.accessioned2018-03-29T01:07:46Z
dc.date.available2018-03-29T01:07:46Z
dc.identifierBmc Genomics. v. 9, p. 548, 2008.
dc.identifier1471-2164
dc.identifier10.1186/1471-2164-9-548
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19019209
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198043
dc.identifier19019209
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298276
dc.descriptionThe basidiomycete fungus Moniliophthora perniciosa is the causal agent of Witches' Broom Disease (WBD) in cacao (Theobroma cacao). It is a hemibiotrophic pathogen that colonizes the apoplast of cacao's meristematic tissues as a biotrophic pathogen, switching to a saprotrophic lifestyle during later stages of infection. M. perniciosa, together with the related species M. roreri, are pathogens of aerial parts of the plant, an uncommon characteristic in the order Agaricales. A genome survey (1.9x coverage) of M. perniciosa was analyzed to evaluate the overall gene content of this phytopathogen. Genes encoding proteins involved in retrotransposition, reactive oxygen species (ROS) resistance, drug efflux transport and cell wall degradation were identified. The great number of genes encoding cytochrome P450 monooxygenases (1.15% of gene models) indicates that M. perniciosa has a great potential for detoxification, production of toxins and hormones; which may confer a high adaptive ability to the fungus. We have also discovered new genes encoding putative secreted polypeptides rich in cysteine, as well as genes related to methylotrophy and plant hormone biosynthesis (gibberellin and auxin). Analysis of gene families indicated that M. perniciosa have similar amounts of carboxylesterases and repertoires of plant cell wall degrading enzymes as other hemibiotrophic fungi. In addition, an approach for normalization of gene family data using incomplete genome data was developed and applied in M. perniciosa genome survey. This genome survey gives an overview of the M. perniciosa genome, and reveals that a significant portion is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle. Our analysis provides new evidence revealing potential adaptive traits that may play major roles in the mechanisms of pathogenicity in the M. perniciosa/cacao pathosystem.
dc.description9
dc.description548
dc.languageeng
dc.relationBmc Genomics
dc.relationBMC Genomics
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAgaricales
dc.subjectCacao
dc.subjectCluster Analysis
dc.subjectDna, Fungal
dc.subjectExpressed Sequence Tags
dc.subjectGenes, Fungal
dc.subjectGenome, Fungal
dc.subjectGenomics
dc.subjectModels, Genetic
dc.subjectMultigene Family
dc.subjectPlant Diseases
dc.subjectSequence Alignment
dc.subjectSequence Analysis, Dna
dc.titleA Genome Survey Of Moniliophthora Perniciosa Gives New Insights Into Witches' Broom Disease Of Cacao.
dc.typeArtículos de revistas


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