Diet-induced Inflammation Of The Hypothalamus In Obesity.

dc.creatorVelloso, Lício A
dc.creatorAraújo, Eliana P
dc.creatorde Souza, Cláudio T
dc.date2008
dc.date2015-11-27T13:13:11Z
dc.date2015-11-27T13:13:11Z
dc.date.accessioned2018-03-29T01:07:29Z
dc.date.available2018-03-29T01:07:29Z
dc.identifierNeuroimmunomodulation. v. 15, n. 3, p. 189-93, 2008.
dc.identifier1423-0216
dc.identifier10.1159/000153423
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18781083
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197970
dc.identifier18781083
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298203
dc.descriptionDysfunction of specific hypothalamic neurons is regarded as an important mechanism predisposing to the development of obesity. Recent studies have revealed that the consumption of fat-rich foods can activate an inflammatory response in the hypothalamus, which disturbs the anorexigenic and thermogenic signals generated by the hormones leptin and insulin, leading in turn to anomalous body mass control. Depending on diet composition, cytokines are expressed in the hypothalamus, contributing to the activation of intracellular inflammatory signal transduction. At least 4 distinct signaling pathways have been identified and the molecular mechanisms leading to the impairment of the leptin and insulin actions have been determined. Here, we present the mechanisms involved in diet-induced resistance to leptin and insulin action in the hypothalamus and discuss some of the potential applications of this knowledge in the therapeutics of obesity.
dc.description15
dc.description189-93
dc.languageeng
dc.relationNeuroimmunomodulation
dc.relationNeuroimmunomodulation
dc.rightsfechado
dc.rights2008 S. Karger AG, Basel.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBody Weight
dc.subjectCytokines
dc.subjectDietary Fats
dc.subjectEncephalitis
dc.subjectHumans
dc.subjectHypothalamus
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectLeptin
dc.subjectObesity
dc.subjectSignal Transduction
dc.titleDiet-induced Inflammation Of The Hypothalamus In Obesity.
dc.typeArtículos de revistas


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