Phenobarbital Influence On Neuromuscular Block Produced By Rocuronium In Rats.

dc.creatorBraga, Angélica de Fátima de Assunção
dc.creatorBarcelos, Caroline Coutinho de
dc.creatorBraga, Franklin Sarmento da Silva
dc.creatorFernandes, Samanta Cristina Antoniassi
dc.creatorFranco, Yoko Oshima
dc.creatorMantovani, Mario
dc.creatorSimioni, Léa Rodrigues
dc.date
dc.date2015-11-27T13:13:01Z
dc.date2015-11-27T13:13:01Z
dc.date.accessioned2018-03-29T01:07:11Z
dc.date.available2018-03-29T01:07:11Z
dc.identifierActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 23, n. 4, p. 343-7
dc.identifier1678-2674
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18641804
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197897
dc.identifier18641804
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298130
dc.descriptionTo evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes. Thirty rats were included in the study and distributed into 6 groups of 5 animals each. Rats were treated for seven days with phenobarbital (20 mg/kg) and the following parameters were evaluated: 1) the amplitude of muscle response in the preparation of rats exposed to phenobarbital; 2) rocuronium effect on rat preparation exposed or not to phenobarbital; 3) concentrations of cytochrome P450 and cytochrome b5 in hepatic microsomes isolated from rats exposed or not to phenobarbital. The concentration and dose of rocuronium used in vitro and in vivo experiments were 4 microg/mL and 0,6 mg/kg, respectively. Phenobarbital in vitro and in vivo did not alter the amplitude of muscle response. The neuromuscular blockade in vitro produced by rocuronium was significantly different (p=0.019) between exposed (20%) and not exposed (60%) rats; the blockade in vivo was significantly greater (p=0.0081) in treated rats (93.4%). The enzymatic concentrations were significantly greater in rats exposed to phenobarbital. Phenobarbital alone did not compromise neuromuscular transmission. It produced enzymatic induction, and neuromuscular blockade in vivo produced by rocuronium was potentiated by phenobarbital.
dc.description23
dc.description343-7
dc.languageeng
dc.relationActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia
dc.relationActa Cir Bras
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAndrostanols
dc.subjectAnimals
dc.subjectCytochrome P-450 Enzyme System
dc.subjectCytochromes B5
dc.subjectDrug Evaluation, Preclinical
dc.subjectHypnotics And Sedatives
dc.subjectMale
dc.subjectMicrosomes, Liver
dc.subjectNeuromuscular Blockade
dc.subjectNeuromuscular Junction
dc.subjectNeuromuscular Nondepolarizing Agents
dc.subjectPhenobarbital
dc.subjectRats
dc.subjectSynaptic Transmission
dc.titlePhenobarbital Influence On Neuromuscular Block Produced By Rocuronium In Rats.
dc.typeArtículos de revistas


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