Ablation Of Primary Afferent Neurons By Neonatal Capsaicin Treatment Reduces The Susceptibility Of The Portal Hypertensive Gastric Mucosa To Ethanol-induced Injury In Cirrhotic Rats.

dc.creatorCamara, Paula R S
dc.creatorFerraz, Gerson J N
dc.creatorFranco-Penteado, Carla F
dc.creatorSbragia-Neto, Lourenco
dc.creatorMeirelles, Luciana R
dc.creatorTeixeira, Simone A
dc.creatorMuscara, Marcelo N
dc.creatorVelloso, Licio A
dc.creatorAntunes, Edson
dc.creatorFerraz, Jose G P
dc.date2008-Jul
dc.date2015-11-27T13:12:55Z
dc.date2015-11-27T13:12:55Z
dc.date.accessioned2018-03-29T01:07:00Z
dc.date.available2018-03-29T01:07:00Z
dc.identifierEuropean Journal Of Pharmacology. v. 589, n. 1-3, p. 245-50, 2008-Jul.
dc.identifier0014-2999
dc.identifier10.1016/j.ejphar.2008.05.004
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18555214
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197845
dc.identifier18555214
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298078
dc.descriptionPrimary sensory afferent neurons modulate the hyperdynamic circulation in cirrhotic rats with portal hypertension. The stomach of cirrhotic rats is prone to damage induced by ethanol, a phenomenon associated with reduced gastric hyperemic response to acid-back diffusion. The aim of this study was to examine the impact of ablation of capsaicin-sensitive neurons and the tachykinin NK(1) receptor antagonist A5330 on the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury and its effects on gastric cyclooxygenase (COX) and nitric oxide synthase (NOS) mRNA expression. Capsaicin was administered to neonatal, male, Wistar rats and the animals were allowed to grow. Cirrhosis was then induced by bile duct ligation in adult rats while controls had sham operation. Ethanol-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow was measured as well as COX/NOS mRNA expression. Topical application of ethanol produced significant gastric damage in cirrhotic rats compared to controls, which was reversed in capsaicin- and A5330-treated animals. Mean arterial and portal pressure was normalized in capsaicin-treated cirrhotic rats. Capsaicin and A5330 administration restored gastric blood flow responses to topical application of ethanol followed by acid in cirrhotic rats. Differential COX and NOS mRNA expression was noted in bile duct ligated rats relative to controls. Capsaicin treatment significantly modified gastric eNOS/iNOS/COX-2 mRNA expression in cirrhotic rats. Capsaicin-sensitive neurons modulate the susceptibility of the portal hypertensive gastric mucosa to injury induced by ethanol via tachykinin NK(1) receptors and signalling of prostaglandin and NO production/release.
dc.description589
dc.description245-50
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBlood Pressure
dc.subjectCapsaicin
dc.subjectCommon Bile Duct
dc.subjectEthanol
dc.subjectGastric Mucosa
dc.subjectGene Expression Regulation, Enzymologic
dc.subjectHypertension, Portal
dc.subjectLigation
dc.subjectLiver
dc.subjectLiver Cirrhosis, Experimental
dc.subjectMale
dc.subjectNeurokinin-1 Receptor Antagonists
dc.subjectNeurons, Afferent
dc.subjectNitric Oxide Synthase
dc.subjectPortal Pressure
dc.subjectProstaglandin-endoperoxide Synthases
dc.subjectRna, Messenger
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Neurokinin-1
dc.subjectRegional Blood Flow
dc.subjectSignal Transduction
dc.subjectTime Factors
dc.titleAblation Of Primary Afferent Neurons By Neonatal Capsaicin Treatment Reduces The Susceptibility Of The Portal Hypertensive Gastric Mucosa To Ethanol-induced Injury In Cirrhotic Rats.
dc.typeArtículos de revistas


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