Disodium Cromoglycate Protects Dystrophin-deficient Muscle Fibers From Leakiness.

dc.creatorMarques, Maria Julia
dc.creatorVentura Machado, Rafael
dc.creatorMinatel, Elaine
dc.creatorSanto Neto, Humberto
dc.date2008-Jan
dc.date2015-11-27T13:12:45Z
dc.date2015-11-27T13:12:45Z
dc.date.accessioned2018-03-29T01:06:41Z
dc.date.available2018-03-29T01:06:41Z
dc.identifierMuscle & Nerve. v. 37, n. 1, p. 61-7, 2008-Jan.
dc.identifier0148-639X
dc.identifier10.1002/mus.20892
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17724738
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197774
dc.identifier17724738
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298007
dc.descriptionIn dystrophin-deficient fibers of mdx mice and in Duchenne dystrophy, the lack of dystrophin leads to sarcolemma breakdown and muscle degeneration. We verified that cromolyn, a mast-cell stabilizer agent, stabilized dystrophic muscle fibers using Evans blue dye as a marker of sarcolemma leakiness. Mdx mice (n=8; 14 days of age) received daily intraperitoneal injections of cromolyn (50 mg/kg body weight) for 15 days. Untreated mdx mice (n=8) were injected with saline. Cryostat cross-sections of the sternomastoid, tibialis anterior, and diaphragm muscles were stained with hematoxylin and eosin. Cromolyn dramatically reduced Evans blue dye-positive fibers in all muscles (P<0.05; Student's t-test) and led to a significant increase in the percentage of fibers with peripheral nuclei. This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin.
dc.description37
dc.description61-7
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-asthmatic Agents
dc.subjectCell Membrane Permeability
dc.subjectCromolyn Sodium
dc.subjectDisease Models, Animal
dc.subjectDystrophin
dc.subjectFemale
dc.subjectIon Channels
dc.subjectIons
dc.subjectMale
dc.subjectMast Cells
dc.subjectMice
dc.subjectMice, Inbred Mdx
dc.subjectMuscle Fibers, Skeletal
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophy, Animal
dc.subjectMuscular Dystrophy, Duchenne
dc.subjectSarcolemma
dc.subjectTreatment Outcome
dc.subjectWater-electrolyte Balance
dc.titleDisodium Cromoglycate Protects Dystrophin-deficient Muscle Fibers From Leakiness.
dc.typeArtículos de revistas


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