Antithrombogenic Polynitrosated Polyester/poly(methyl Methacrylate) Blend For The Coating Of Blood-contacting Surfaces.

dc.creatorSeabra, Amedea B
dc.creatorda Silva, Regiane
dc.creatorde Souza, Gabriela F P
dc.creatorde Oliveira, Marcelo G
dc.date2008-Apr
dc.date2015-11-27T13:12:38Z
dc.date2015-11-27T13:12:38Z
dc.date.accessioned2018-03-29T01:06:30Z
dc.date.available2018-03-29T01:06:30Z
dc.identifierArtificial Organs. v. 32, n. 4, p. 262-7, 2008-Apr.
dc.identifier1525-1594
dc.identifier10.1111/j.1525-1594.2008.00540.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18370938
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197723
dc.identifier18370938
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297956
dc.descriptionA nitric oxide (NO) donor polyester containing multiple S-nitrosothiol (S-NO) groups covalently attached to the polymer backbone was synthesized through the esterification of poly(ethylene glycol) with mercaptosuccinic acid, followed by the nitrosation of the -SH moieties. The polynitrosated polyester (PNPE) obtained was blended with poly(methyl methacrylate) (PMMA), yielding solid films capable of releasing NO. Scanning electron microscopy analysis showed that acrylic plates and stainless steel intracoronary stents can be coated with continuous and adherent PNPE/PMMA films. After an initial NO burst, these films release NO spontaneously in dry condition or immersed in aqueous solution at constant rates of 1.8 and 180 nmol/g/h, respectively, for more than 24 h at physiological temperature. PNPE/PMMA coated surfaces were shown to inhibit platelet adhesion when in contact with whole blood. These results show that PNPE/PMMA blend can be used for the coating of blood-contacting surfaces, with potential to inhibit thrombosis and restenosis after stenting.
dc.description32
dc.description262-7
dc.languageeng
dc.relationArtificial Organs
dc.relationArtif Organs
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcrylates
dc.subjectBiocompatible Materials
dc.subjectBlood Platelets
dc.subjectCoronary Restenosis
dc.subjectDelayed-action Preparations
dc.subjectDrug-eluting Stents
dc.subjectFibrinolytic Agents
dc.subjectHumans
dc.subjectKinetics
dc.subjectMaterials Testing
dc.subjectNitric Oxide
dc.subjectNitric Oxide Donors
dc.subjectPlatelet Adhesiveness
dc.subjectPolyesters
dc.subjectPolymethyl Methacrylate
dc.subjectProsthesis Design
dc.subjectS-nitrosothiols
dc.subjectStainless Steel
dc.subjectSurface Properties
dc.subjectThrombosis
dc.titleAntithrombogenic Polynitrosated Polyester/poly(methyl Methacrylate) Blend For The Coating Of Blood-contacting Surfaces.
dc.typeArtículos de revistas


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