Ganglioside Gm1 Effects On The Expression Of Nerve Growth Factor (ngf), Trk-a Receptor, Proinflammatory Cytokines And On Autoimmune Diabetes Onset In Non-obese Diabetic (nod) Mice.

dc.creatorVieira, Karla Priscila
dc.creatorde Almeida e Silva Lima Zollner, Ana Rachel
dc.creatorMalaguti, Carina
dc.creatorVilella, Conceição Aparecida
dc.creatorde Lima Zollner, Ricardo
dc.date2008-Apr
dc.date2015-11-27T13:12:35Z
dc.date2015-11-27T13:12:35Z
dc.date.accessioned2018-03-29T01:06:25Z
dc.date.available2018-03-29T01:06:25Z
dc.identifierCytokine. v. 42, n. 1, p. 92-104, 2008-Apr.
dc.identifier1096-0023
dc.identifier10.1016/j.cyto.2008.01.009
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18329889
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197704
dc.identifier18329889
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297937
dc.descriptionNOD (non-obese diabetic) mice develop type 1 diabetes mellitus spontaneously and with a strong similarity to the human disease. Differentiation and function of pancreas beta cells are regulated by a variety of hormones and growth factors, including the nerve growth factor (NGF). Gangliosides have multiple immunomodulatory activities with immunosuppressive properties, decreasing lymphoproliferative responses and modulating cytokine production. In the present study, serum, pancreas islets and spleen mononuclear cells from NOD mice treated with monosialic ganglioside GM1 (100 mg/kg/day) and the group control which received saline solution were isolated to investigate the proinflammatory cytokines (IL-1beta, IFN-gamma, IL-12, TNF-alpha), NGF and its high-affinity receptor TrkA, peri-islet Schwann cells components (GFAP, S100-beta) expression and the relationship with diabetes onset and morphological aspects. Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha and IL-1beta). Furthermore, GM1 increases GFAP, S-100beta and NGF in pancreas islets, factors involved in beta cell survival.
dc.description42
dc.description92-104
dc.languageeng
dc.relationCytokine
dc.relationCytokine
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAge Of Onset
dc.subjectAnimals
dc.subjectCytokines
dc.subjectDiabetes Mellitus, Type 1
dc.subjectFemale
dc.subjectG(m1) Ganglioside
dc.subjectHumans
dc.subjectIslets Of Langerhans
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Nod
dc.subjectNerve Growth Factor
dc.subjectNerve Growth Factors
dc.subjectNerve Tissue Proteins
dc.subjectReceptor, Trka
dc.subjectS100 Calcium Binding Protein Beta Subunit
dc.subjectS100 Proteins
dc.subjectSchwann Cells
dc.subjectSpleen
dc.titleGanglioside Gm1 Effects On The Expression Of Nerve Growth Factor (ngf), Trk-a Receptor, Proinflammatory Cytokines And On Autoimmune Diabetes Onset In Non-obese Diabetic (nod) Mice.
dc.typeArtículos de revistas


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