The Prognostic Value Of Maturation-associated Phenotypic Abnormalities In Myelodysplastic Syndromes.

dc.creatorLorand-Metze, I
dc.creatorCalifani, S M V
dc.creatorRibeiro, E
dc.creatorLima, C S P
dc.creatorMetze, K
dc.date2008-Feb
dc.date2015-11-27T13:12:29Z
dc.date2015-11-27T13:12:29Z
dc.date.accessioned2018-03-29T01:06:18Z
dc.date.available2018-03-29T01:06:18Z
dc.identifierLeukemia Research. v. 32, n. 2, p. 211-3, 2008-Feb.
dc.identifier0145-2126
dc.identifier10.1016/j.leukres.2007.06.014
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17675154
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197675
dc.identifier17675154
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297908
dc.descriptionSeveral phenotypic abnormalities of bone marrow (BM) hemopoietic precursors have been associated with disease progression in myelodysplastic syndromes (MDS). We analyzed the influence on overall survival of the expression of lineage and maturation-associated antigens of BM hemopoietic cells quantified in a previous study. In the univariate Cox regression the peripheral platelet count was a significant favourable factor for overall survival. Unfavorable prognostic factors were: WPSS, increase in BM CD34+ cells, increased mean fluorescence intensity (MFI) of CD13 on myelocytes, metamyelocytes and mature neutrophils as well as increased CD45 of myelocytes and mature neutrophils. In a model containing platelet count, WPSS and MFI of CD45 and CD13 on mature neutrophils, only hyperexpression of CD13 and degree of thrombocytopenia were independent risk factors. Therefore, phenotypic features that can also be obtained from PB might be useful for predicting survival in MDS.
dc.description32
dc.description211-3
dc.languageeng
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectAntigens, Cd13
dc.subjectAntigens, Cd34
dc.subjectAntigens, Cd45
dc.subjectBone Marrow Cells
dc.subjectCell Lineage
dc.subjectFlow Cytometry
dc.subjectHematopoietic Stem Cells
dc.subjectHumans
dc.subjectImmunophenotyping
dc.subjectMiddle Aged
dc.subjectMyelodysplastic Syndromes
dc.subjectPhenotype
dc.subjectPlatelet Count
dc.subjectPrognosis
dc.subjectTumor Markers, Biological
dc.titleThe Prognostic Value Of Maturation-associated Phenotypic Abnormalities In Myelodysplastic Syndromes.
dc.typeArtículos de revistas


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