Serum Interleukin-18 And Soluble Tumour Necrosis Factor Receptor 2 Are Associated With Disease Severity In Patients With Paracoccidioidomycosis.

dc.creatorCorvino, C L
dc.creatorMamoni, R L
dc.creatorFagundes, G Z Z
dc.creatorBlotta, M H S L
dc.date2007-Mar
dc.date2015-11-27T13:10:53Z
dc.date2015-11-27T13:10:53Z
dc.date.accessioned2018-03-29T01:06:16Z
dc.date.available2018-03-29T01:06:16Z
dc.identifierClinical And Experimental Immunology. v. 147, n. 3, p. 483-90, 2007-Mar.
dc.identifier0009-9104
dc.identifier10.1111/j.1365-2249.2006.03308.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17302897
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197663
dc.identifier17302897
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297896
dc.descriptionInterleukin (IL)-18 is a proinflammatory cytokine of the IL-1 superfamily that exhibits broad functional effects in innate and acquired immune responses and which has been found in high levels in several chronic inflammatory and autoimmune diseases. Over-expression of IL-18 may promote early resolution of infection or could promote a detrimental exaggerated immune response. The aim of this study was to determine serum levels of IL-18 and other inflammatory mediators [IL-12, soluble intercellular adhesion molecule 1 (sICAM-1), soluble tumour necrosis factor receptor 1 (TNF-RI), sTNF-RII, CXC chemokine ligand 9 (CXCL9), CXCL10] at baseline and after anti-fungal therapy in serum from patients with juvenile (JF) and adult (AF) forms of paracoccidioidomycosis (PCM), as well as in healthy controls (C), and to assess their possible relationships to the severity of disease. IL-18 and sTNF-RII levels in patients with the JF of PCM were significantly higher than those in the AF and controls. In relation to sICAM-1, no difference was observed between JF and AF patients but both presented higher levels than controls. sTNF-RI levels were higher in patients with PCM than in controls, and significantly higher concentrations were detected in AF patients compared to JF patients. Moreover, IL-12 and chemokines CXCL9 and CXCL10 were also higher in patients than in controls. In JF patients IL-18 levels correlated significantly with sICAM-1 (r=0 x 62, P<0 x 0001), sTNF-RI (r=0 x 63, P<0 x 0001), sTNF-RII (r=0 x 51, P=0 x 02), as well as with clinical severity. The results suggest the value of serum IL-18 and sTNF-Rs levels as a parameter of PCM severity and may support a possible role for them in the pathogenesis of the disease.
dc.description147
dc.description483-90
dc.languageeng
dc.relationClinical And Experimental Immunology
dc.relationClin. Exp. Immunol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAntibodies, Fungal
dc.subjectAntifungal Agents
dc.subjectBiological Markers
dc.subjectChemokines
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunoglobulin E
dc.subjectImmunoglobulin G
dc.subjectInflammation Mediators
dc.subjectInterleukin-18
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParacoccidioides
dc.subjectParacoccidioidomycosis
dc.subjectReceptors, Tumor Necrosis Factor, Type Ii
dc.subjectRetrospective Studies
dc.subjectSolubility
dc.titleSerum Interleukin-18 And Soluble Tumour Necrosis Factor Receptor 2 Are Associated With Disease Severity In Patients With Paracoccidioidomycosis.
dc.typeArtículos de revistas


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