Cyclic Guanosine Monophosphate Phosphodiesterase-5 Inhibitor Promotes An Endothelium No-dependent-like Vasodilation In Patients With Refractory Hypertension.

dc.creatorYugar-Toledo, Juan Carlos
dc.creatorFerreira-Melo, Sílvia E
dc.creatorConsolim-Colombo, Fernanda M
dc.creatorIrigoyen, Maria C
dc.creatorCoelho, Otávio Rizzi
dc.creatorMoreno, Heitor
dc.date2007-May
dc.date2015-11-27T13:10:52Z
dc.date2015-11-27T13:10:52Z
dc.date.accessioned2018-03-29T01:06:14Z
dc.date.available2018-03-29T01:06:14Z
dc.identifierNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society. v. 16, n. 3, p. 315-21, 2007-May.
dc.identifier1089-8603
dc.identifier10.1016/j.niox.2006.12.004
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17276107
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197654
dc.identifier17276107
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297887
dc.descriptionThe nitric oxide/cyclic-guanosine 3',5'-monophosphate signaling cascade plays an essential role in cardiovascular homeostasis but its involvement in the pathophysiology of refractory hypertension is unclear. The acute vasodilatory effect of a single oral dose of a phosphodiesterase-5 inhibitor (sildenafil citrate) on the brachial artery dilatation was evaluated in 25 normal healthy volunteers (NL) and in 25 refractory hypertensive patients (RH). Endothelial and vascular smooth muscle functions were assessed two times. First, the brachial artery response to endothelium-dependent (flow-mediated dilatation [FMD]) and independent (glyceryl trinitrate [GTN]) stimuli was examined. The FMD in NL was 14.2+/-3.2% compared to 10.3+/-3.5% in RH (P<0.001) and the GTN-induced responses were 23.5+/-6.3 in NL compared to 18.4+/-5.7% in RH (P<0.001). Two weeks later, the brachial artery responses to FMD were determined before and after the administration of sildenafil citrate. Sildenafil caused a significant, slow and progressive dilatation of the brachial artery until 45 min after administration (4.7+/-3.0%, 6.7+/-3.0% and 9.4+/-3.9% after 15', 30' and 45', respectively, in RH and 3.7+/-1.9%, 7.4+/-2.7% and 10.1+/-3.0%, respectively, in NL). A second FMD stimulus, applied 45 min after ingesting 50mg of sildenafil resulted in an additional significant increase in the vasodilatory response (from 9.4+/-3.9% to 13.0+/-4.0% in RH; P<0.001 and from 10.1+/-3.0 to 14.6+/-4.1 in NL; P<0.001), but this was still significantly less than the response to GTN. Sildenafil citrate caused brachial artery vasodilatation similar to that caused by NO released during FMD in patients with refractory hypertension.
dc.description16
dc.description315-21
dc.languageeng
dc.relationNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society
dc.relationNitric Oxide
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subject3',5'-cyclic-gmp Phosphodiesterases
dc.subjectAdult
dc.subjectCyclic Gmp
dc.subjectCyclic Nucleotide Phosphodiesterases, Type 5
dc.subjectEndothelium
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNitric Oxide
dc.subjectNitroglycerin
dc.subjectPhosphodiesterase Inhibitors
dc.subjectPiperazines
dc.subjectPurines
dc.subjectSignal Transduction
dc.subjectSulfones
dc.subjectVasodilation
dc.subjectVasodilator Agents
dc.titleCyclic Guanosine Monophosphate Phosphodiesterase-5 Inhibitor Promotes An Endothelium No-dependent-like Vasodilation In Patients With Refractory Hypertension.
dc.typeArtículos de revistas


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