Accelerated Atherogenesis And Neointima Formation In Heparin Cofactor Ii Deficient Mice.

dc.creatorVicente, Cristina P
dc.creatorHe, Li
dc.creatorTollefsen, Douglas M
dc.date2007-Dec
dc.date2015-11-27T13:10:29Z
dc.date2015-11-27T13:10:29Z
dc.date.accessioned2018-03-29T01:05:29Z
dc.date.available2018-03-29T01:05:29Z
dc.identifierBlood. v. 110, n. 13, p. 4261-7, 2007-Dec.
dc.identifier0006-4971
dc.identifier10.1182/blood-2007-04-086611
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17878401
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197464
dc.identifier17878401
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297697
dc.descriptionHeparin cofactor II (HCII) is a plasma protein that inhibits thrombin when bound to dermatan sulfate or heparin. HCII-deficient mice are viable and fertile but rapidly develop thrombosis of the carotid artery after endothelial injury. We now report the effects of HCII deficiency on atherogenesis and neointima formation. HCII-null or wild-type mice, both on an apolipoprotein E-null background, were fed an atherogenic diet for 12 weeks. HCII-null mice developed plaque areas in the aortic arch approximately 64% larger than wild-type mice despite having similar plasma lipid and glucose levels. Neointima formation was induced by mechanical dilation of the common carotid artery. Thrombin activity, determined by hirudin binding or chromogenic substrate hydrolysis within 1 hour after injury, was higher in the arterial walls of HCII-null mice than in wild-type mice. After 3 weeks, the median neointimal area was 2- to 3-fold greater in HCII-null than in wild-type mice. Dermatan sulfate administered intravenously within 48 hours after injury inhibited neointima formation in wild-type mice but had no effect in HCII-null mice. Heparin did not inhibit neointima formation. We conclude that HCII deficiency promotes atherogenesis and neointima formation and that treatment with dermatan sulfate reduces neointima formation in an HCII-dependent manner.
dc.description110
dc.description4261-7
dc.languageeng
dc.relationBlood
dc.relationBlood
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAorta, Thoracic
dc.subjectAtherosclerosis
dc.subjectCarotid Artery Thrombosis
dc.subjectCarotid Artery, Common
dc.subjectDermatan Sulfate
dc.subjectHeparin Cofactor Ii
dc.subjectMice
dc.subjectMice, Mutant Strains
dc.subjectThrombin
dc.subjectTunica Intima
dc.titleAccelerated Atherogenesis And Neointima Formation In Heparin Cofactor Ii Deficient Mice.
dc.typeArtículos de revistas


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