Study Of A Microwave Assisted Vacuum Drying Process Applied To The Granulated Pharmaceutical Drug Hydrochlorthiazide.

dc.creatorBerteli, Michele N
dc.creatorMarsaioli, Antonio Júnior
dc.creatorRodier, Elisabeth
dc.date2007
dc.date2015-11-27T13:10:26Z
dc.date2015-11-27T13:10:26Z
dc.date.accessioned2018-03-29T01:05:26Z
dc.date.available2018-03-29T01:05:26Z
dc.identifierThe Journal Of Microwave Power And Electromagnetic Energy : A Publication Of The International Microwave Power Institute. v. 40, n. 4, p. 241-50, 2007.
dc.identifier0832-7823
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17847678
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197447
dc.identifier17847678
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297680
dc.descriptionDrying processes have evolved considerably over the years, aiming at the best conditions to shorten the processing time, but maintaining the highest final product quality. The application of vacuums to the microwave drying process might be interesting, especially for thermally sensitive products because the reduced boiling point of the solvent allows a lower temperature processing. The objective of the present work is to study and evaluate the process of drying a granulated product that is the basis of the drug hydrochlorthiazide, with an initial moisture content of 21% in dry basis. This study monitored the drying kinetics, product temperature and power absorbed by the sample using a bench scale vacuum microwave dryer. The equipment consisted of a cylindrical pressure vessel crossed by a wave guide, setting up a system whereby the vacuum pressure, the sample weight and the incident, reflected and residual microwave powers could be measured and evaluated, throughout the entire process. The experimental runs were established with an approximate incident microwave power at 20 W for absolute pressure levels of 50 and 75 mbar, working with samples of about 1.4 g. It was observed that the vacuum microwave process kinetics at both pressure levels showed little difference. The processes were carried out almost entirely in a regime of water evaporation, the product's temperature remaining below the solvent boiling temperature. The drying times were similar for both processes, whereas the absorbed power was slightly higher at the pressure of 75 mbar.
dc.description40
dc.description241-50
dc.languageeng
dc.relationThe Journal Of Microwave Power And Electromagnetic Energy : A Publication Of The International Microwave Power Institute
dc.relationJ Microw Power Electromagn Energy
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAbsorption
dc.subjectAdsorption
dc.subjectCalorimetry
dc.subjectChemistry, Pharmaceutical
dc.subjectEquipment Design
dc.subjectHydrochlorothiazide
dc.subjectKinetics
dc.subjectMicrowaves
dc.subjectPressure
dc.subjectSolvents
dc.subjectTechnology, Pharmaceutical
dc.subjectTemperature
dc.subjectTime Factors
dc.subjectVacuum
dc.titleStudy Of A Microwave Assisted Vacuum Drying Process Applied To The Granulated Pharmaceutical Drug Hydrochlorthiazide.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución