Supplementation With Commercial Mixtures Of Conjugated Linoleic Acid In Association With Vitamin E And The Process Of Lipid Autoxidation In Rats.

dc.creatorSantos-Zago, Lilia Ferreira
dc.creatorBotelho, Adriana Prais
dc.creatorde Oliveira, Admar Costa
dc.date2007-Sep
dc.date2015-11-27T13:10:20Z
dc.date2015-11-27T13:10:20Z
dc.date.accessioned2018-03-29T01:05:14Z
dc.date.available2018-03-29T01:05:14Z
dc.identifierLipids. v. 42, n. 9, p. 845-54, 2007-Sep.
dc.identifier0024-4201
dc.identifier10.1007/s11745-007-3083-z
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17665238
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197399
dc.identifier17665238
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297632
dc.descriptionCLA has been studied for its beneficial effects on health. However, the possibility of adverse effects, such as increased oxidative stress, must also be considered. The present work aims to assess the effect of CLA supplementation on the process of lipid autoxidation, both in the presence and in absence of an antioxidant. The investigation consisted in a biological assay with 60 rats divided into six groups: C (control), CE (control + vitamin E), AE (AdvantEdgeCLA), AEE (AdvantEdgeCLA + Vitamin E), CO (CLA One) and COE (CLA One)+ vitamin E). The CLA amount was 2% of feed consumption. Animals were supplemented for 42 days. As indicators of lipid autoxidation, peroxide (IP), malondialdehyde (MDA), 8-iso-PGF2(alpha) isoprostane and catalase were determined. Hepatic IP results indicated that CLA increased oxidation: values for CLA-supplemented groups, particularly group CO (84.38 +/- 10.97 mequiv/kg), were higher than those of the control group (54.75 +/- 9.70 mequiv/kg). In contrast, serum MDA results showed that CLA reduces oxidation both for group AE (1.8 +/- 0.67 mg of MDA/l) and for group CO (2.43 +/- 0.61 mg of MDA/l) as compared to the control group (3.85 +/- 0.24 mg of MDA/l). Serum catalase indicated a reduction of oxidation: groups AE and CO displayed 4734.23 +/- 1078.93 kU/l and 5916.06 +/- 2490.71 kU/l, respectively. These values are significantly lower than those of the control group. An increase in 8-iso-PGF2(alpha) in urine was observed, particularly in group AE (95.13 +/- 20.26 pg/ml) as compared to the control group (69.46 +/- 16.65 pg/ml). It was concluded that the influence of CLA on lipid autoxidation is dependent on supplement type, supplement dosage and chosen indicator, including its tissue and determination methodology.
dc.description42
dc.description845-54
dc.languageeng
dc.relationLipids
dc.relationLipids
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectDietary Supplements
dc.subjectDinoprost
dc.subjectDose-response Relationship, Drug
dc.subjectLinoleic Acids, Conjugated
dc.subjectLipid Metabolism
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectOxidation-reduction
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.subjectVitamin E
dc.titleSupplementation With Commercial Mixtures Of Conjugated Linoleic Acid In Association With Vitamin E And The Process Of Lipid Autoxidation In Rats.
dc.typeArtículos de revistas


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