Hypertension Increases Retinal Inflammation In Experimental Diabetes: A Possible Mechanism For Aggravation Of Diabetic Retinopathy By Hypertension.

dc.creatorSilva, Kamila C
dc.creatorPinto, Camila C
dc.creatorBiswas, Subrata K
dc.creatorde Faria, José B Lopes
dc.creatorde Faria, Jacqueline M Lopes
dc.date2007-Jun
dc.date2015-11-27T13:10:17Z
dc.date2015-11-27T13:10:17Z
dc.date.accessioned2018-03-29T01:05:08Z
dc.date.available2018-03-29T01:05:08Z
dc.identifierCurrent Eye Research. v. 32, n. 6, p. 533-41, 2007-Jun.
dc.identifier0271-3683
dc.identifier10.1080/02713680701435391
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17612969
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197373
dc.identifier17612969
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297606
dc.descriptionInflammation is pivotal to the pathogenesis of diabetic retinopathy (DR). Hypertension is the main secondary risk factor associated with DR. The mechanisms by which hypertension increases the risk for DR are poorly understood. The aim of the current study was to investigate the contribution of genetic hypertension to early retinal inflammation in experimental diabetes. Diabetes was induced in 4-week-old (developing hypertension) and 12-week-old (fully hypertensive) spontaneously hypertensive rats (SHR) and age-matched control normotensive Wistar Kyoto (WKY) rats by administration of streptozotocin (50 mg/kg, i.v); after 20 days the rats were sacrificed and the retinas were collected. ED1 positive cells, ICAM-1 and VEGF levels were significantly higher in diabetic SHR in both prehypertensive and hypertensive ages (p < 0.005). NF-kappaB p65 levels were higher in prehypertensive SHR and in hypertensive diabetic SHR (p < 0.05). Induction of diabetes in normotensive WKY rats did not show any alteration in retinal expression of inflammatory parameters. Therefore, we conclude that the developing hypertension and also the fully developed hypertension lead to earlier development of inflammation in diabetic retina. Aggravation of the inflammatory process may be involved in the mechanism by which essential hypertension exacerbates retinopathy in the presence of diabetes.
dc.description32
dc.description533-41
dc.languageeng
dc.relationCurrent Eye Research
dc.relationCurr. Eye Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlotting, Western
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Retinopathy
dc.subjectEctodysplasins
dc.subjectHypertension
dc.subjectImmunoenzyme Techniques
dc.subjectIntercellular Adhesion Molecule-1
dc.subjectMacrophages
dc.subjectMicroglia
dc.subjectRats
dc.subjectRats, Inbred Shr
dc.subjectRats, Inbred Wky
dc.subjectRetinitis
dc.subjectTranscription Factor Rela
dc.subjectVascular Endothelial Growth Factor A
dc.titleHypertension Increases Retinal Inflammation In Experimental Diabetes: A Possible Mechanism For Aggravation Of Diabetic Retinopathy By Hypertension.
dc.typeArtículos de revistas


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