[evidences For Subclinic Chronic Autoimmune Thyroid Disease In Girls With Turner Syndrome].

dc.creatorMedeiros, Carla C M
dc.creatorLemos-Marini, Sofia H V de
dc.creatorBrícola Filho, Milton
dc.creatorCamargo, Edwaldo E
dc.creatorSantos, Allan O
dc.creatorMagna, Luis A
dc.creatorGuerra Júnior, Gil
dc.creatorBaptista, Maria Tereza M
dc.creatorMaciel-Guerra, Andréa T
dc.date2007-Apr
dc.date2015-11-27T13:10:10Z
dc.date2015-11-27T13:10:10Z
dc.date.accessioned2018-03-29T01:04:56Z
dc.date.available2018-03-29T01:04:56Z
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. v. 51, n. 3, p. 401-9, 2007-Apr.
dc.identifier0004-2730
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17546238
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197320
dc.identifier17546238
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297553
dc.descriptionPatients with Turner syndrome (TS) frequently exhibit transient, recurrent and asymptomatic variations of TSH and/or thyroid hormones (TH). This work was carried out to evaluate thyroid function and structure in patients with TS who had had such variations in hormone concentrations. Our sample comprised 24 patients, 17 less than 20-years old. Evaluation included serum levels of TSH, free T4, total T3, TPO and Tg autoantibodies, thyroid ultrasound (US) and scintigraphy with 99mTc-pertechnetate. Thirteen patients had abnormal TSH and/or TH levels; 23 exhibited US features compatible with chronic thyroid disorder, particularly thyromegaly (established according to volume expected for stature) and heterogeneous echogenicity. Uptake was normal in 21 cases and tracer distribution was homogeneous in 22. The finding of abnormal hormone concentrations was independent of age, length of time since the first similar finding, thyroid autoantibodies, number of abnormalities at US and abnormal scintigraphic findings. Patients aged more than 20 years had higher frequency of thyroid antibodies and heterogeneous echogenicity, and thyroid volume was significantly correlated to length of time since detection of the first hormone variation, indicating progressive thyroid disease. These results suggest that subclinical thyroid dysfunction in TS is due to chronic autoimmune thyroid disease.
dc.description51
dc.description401-9
dc.languagepor
dc.relationArquivos Brasileiros De Endocrinologia E Metabologia
dc.relationArq Bras Endocrinol Metabol
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAutoantibodies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectRadiopharmaceuticals
dc.subjectSodium Pertechnetate Tc 99m
dc.subjectSyndrome
dc.subjectThyroid Function Tests
dc.subjectThyroid Gland
dc.subjectThyroid Hormones
dc.subjectThyroiditis, Autoimmune
dc.subjectThyrotropin
dc.subjectThyroxine
dc.subjectTriiodothyronine
dc.subjectTurner Syndrome
dc.title[evidences For Subclinic Chronic Autoimmune Thyroid Disease In Girls With Turner Syndrome].
dc.typeArtículos de revistas


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