[insulin And Angiotensin Ii Signaling Pathways Cross-talk: Implications With The Association Between Diabetes Mellitus, Arterial Hypertension And Cardiovascular Disease].

dc.creatorCarvalho-Filho, Marco A de
dc.creatorCarvalheira, José Barreto C
dc.creatorVelloso, Lício Augusto
dc.creatorSaad, Mario José Abdalla
dc.date2007-Mar
dc.date2015-11-27T13:10:06Z
dc.date2015-11-27T13:10:06Z
dc.date.accessioned2018-03-29T01:04:49Z
dc.date.available2018-03-29T01:04:49Z
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. v. 51, n. 2, p. 195-203, 2007-Mar.
dc.identifier0004-2730
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17505626
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197289
dc.identifier17505626
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297522
dc.descriptionInsulin (Ins) and angiotensin II (AII) play pivotal roles in the control of two vital and closely related systems: the metabolic and the circulatory, respectively. A failure in the proper action of each of these hormones results, to a variable degree, in the development of two highly prevalent and commonly overlapping diseases--diabetes mellitus (DM) and hypertension (AH). In recent years, a series of studies has revealed a tight connection between the signal transduction pathways that mediate Ins and AII actions in target tissues. This molecular cross-talk occurs at multiple levels and plays an important role in phenomena that range from the action of anti-hypertensive drugs to cardiac hypertrophy and energy acquisition by the heart. At the extracellular level, the angiotensin-converting enzyme controls AII synthesis but also interferes with Ins signaling through the proper regulation of AII and the accumulation of bradykinin. At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway. Finally, by inducing the expression of the regulatory protein SOCS-3, AII may impose a late control on the Ins signal. This review will focus on the main advances obtained in this field and will discuss the implications of this molecular cross-talk in the common clinical association between DM and AH.
dc.description51
dc.description195-203
dc.languagepor
dc.relationArquivos Brasileiros De Endocrinologia E Metabologia
dc.relationArq Bras Endocrinol Metabol
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAngiotensin Ii
dc.subjectAnimals
dc.subjectDiabetes Mellitus
dc.subjectHumans
dc.subjectHypertension
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMap Kinase Signaling System
dc.subjectSignal Transduction
dc.subjectSuppressor Of Cytokine Signaling Proteins
dc.title[insulin And Angiotensin Ii Signaling Pathways Cross-talk: Implications With The Association Between Diabetes Mellitus, Arterial Hypertension And Cardiovascular Disease].
dc.typeArtículos de revistas


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