Three New Alpha-globin Variants: Hb Itapira [alpha30(b11)glu-->val (alpha1)], Hb Bom Jesus Da Lapa [alpha30(b11)glu-->ala (alpha1)] And Hb Boa Esperança [alpha16(a14)lys-->thr (alpha2)].

dc.creatorJorge, Susan E Costa
dc.creatorKimura, Elza M
dc.creatorOliveira, Denise M
dc.creatorOgo, Satie
dc.creatorAlbuquerque, Dulcinéia M
dc.creatorCosta, Fernando F
dc.creatorSonati, Maria de Fátima
dc.date2007
dc.date2015-11-27T13:10:04Z
dc.date2015-11-27T13:10:04Z
dc.date.accessioned2018-03-29T01:04:46Z
dc.date.available2018-03-29T01:04:46Z
dc.identifierHemoglobin. v. 31, n. 2, p. 151-7, 2007.
dc.identifier0363-0269
dc.identifier10.1080/03630260701289425
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17486496
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197278
dc.identifier17486496
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297511
dc.descriptionThree novel alpha-globin variants were found during a screening program for hemoglobinopathies in blood donors at the UNICAMP Hematology and Hemotherapy Center, Campinas, State of São Paulo, Southeastern Brazil. They were named for the town of origin of the carrier as Hb Itapira [alpha30(B11)Glu-->Val], Hb Bom Jesus da Lapa [alpha30(B11)Glu-->Ala] and Hb Boa Esperança [alpha16(A14)Lys-->Thr]. Hb Itapira, like Hb Bom Jesus da Lapa, shows an electrophoretic mobility similar to that of Hb S [beta6(A3)GluVal, GAG-->GTG] at alkaline pH; it is associated with a triplicate alpha-globin allele (alphaalphaalpha(anti 3.7)) and corresponds to only 5.5% of the total hemoglobin (Hb). Hb Boa Esperança, found in two different individuals, moves faster than Hb A and exhibits an abnormal functional performance.
dc.description31
dc.description151-7
dc.languageeng
dc.relationHemoglobin
dc.relationHemoglobin
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAmino Acid Substitution
dc.subjectBase Sequence
dc.subjectBrazil
dc.subjectDna
dc.subjectFemale
dc.subjectGenetic Variation
dc.subjectGlobins
dc.subjectHemoglobins, Abnormal
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.titleThree New Alpha-globin Variants: Hb Itapira [alpha30(b11)glu-->val (alpha1)], Hb Bom Jesus Da Lapa [alpha30(b11)glu-->ala (alpha1)] And Hb Boa Esperança [alpha16(a14)lys-->thr (alpha2)].
dc.typeArtículos de revistas


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