Protective Effect Of Collagen Derivates On The Ulcerative Lesions Caused By Oral Administration Of Ethanol.

dc.creatorCastro, G A
dc.creatorSgarbieri, V C
dc.creatorCarvalho, J E
dc.creatorTinti, S V
dc.creatorPossenti, A
dc.date2007-Mar
dc.date2015-11-27T13:10:03Z
dc.date2015-11-27T13:10:03Z
dc.date.accessioned2018-03-29T01:04:45Z
dc.date.available2018-03-29T01:04:45Z
dc.identifierJournal Of Medicinal Food. v. 10, n. 1, p. 154-8, 2007-Mar.
dc.identifier1096-620X
dc.identifier10.1089/jmf.2006.262
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17472480
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197271
dc.identifier17472480
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297504
dc.descriptionThe protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.
dc.description10
dc.description154-8
dc.languageeng
dc.relationJournal Of Medicinal Food
dc.relationJ Med Food
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-ulcer Agents
dc.subjectCarbenoxolone
dc.subjectCattle
dc.subjectCollagen
dc.subjectDose-response Relationship, Drug
dc.subjectEthanol
dc.subjectHydrolysis
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectSwine
dc.titleProtective Effect Of Collagen Derivates On The Ulcerative Lesions Caused By Oral Administration Of Ethanol.
dc.typeArtículos de revistas


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