The Mechanism Of Tröger's Base Formation Probed By Electrospray Ionization Mass Spectrometry.

dc.creatorAbella, Carlos A M
dc.creatorBenassi, Mario
dc.creatorSantos, Leonardo S
dc.creatorEberlin, Marcos N
dc.creatorCoelho, Fernando
dc.date2007-May
dc.date2015-11-27T13:10:03Z
dc.date2015-11-27T13:10:03Z
dc.date.accessioned2018-03-29T01:04:45Z
dc.date.available2018-03-29T01:04:45Z
dc.identifierThe Journal Of Organic Chemistry. v. 72, n. 11, p. 4048-54, 2007-May.
dc.identifier0022-3263
dc.identifier10.1021/jo062556w
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17472399
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197270
dc.identifier17472399
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297503
dc.descriptionUsing direct infusion electrospray ionization mass and tandem mass spectrometric experiments [ESI-MS(/MS)], we have performed on-line monitoring of some reactions used to form Tröger's bases. Key intermediates, either as cationic species or as protonated forms of neutral species, have been intercepted and characterized. The role of urotropine as the methylene source in these reactions has also been accessed. Reaction pathways shown by ESI-MS(/MS) have been probed by gas-phase ion/molecule reactions, and an expanded mechanism for Tröger's base formation based on the mass spectrometric data has been elaborated.
dc.description72
dc.description4048-54
dc.languageeng
dc.relationThe Journal Of Organic Chemistry
dc.relationJ. Org. Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAniline Compounds
dc.subjectAzocines
dc.subjectChromatography, Liquid
dc.subjectFormaldehyde
dc.subjectMethenamine
dc.subjectModels, Chemical
dc.subjectModels, Molecular
dc.subjectMolecular Structure
dc.subjectSpectrometry, Mass, Electrospray Ionization
dc.subjectSpectrometry, Mass, Matrix-assisted Laser Desorption-ionization
dc.subjectThromboxane-a Synthase
dc.titleThe Mechanism Of Tröger's Base Formation Probed By Electrospray Ionization Mass Spectrometry.
dc.typeArtículos de revistas


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