Role Of 17 Beta-estradiol On Type Iv Collagen Fibers Volumetric Density In The Basement Membrane Of Bladder Wall.

dc.creatorde Fraga, Rogerio
dc.creatorDambros, Miriam
dc.creatorMiyaoka, Ricardo
dc.creatorRiccetto, Cássio Luís Zanettini
dc.creatorPalma, Paulo César Rodrigues
dc.date2007-Oct
dc.date2015-11-27T13:09:51Z
dc.date2015-11-27T13:09:51Z
dc.date.accessioned2018-03-29T01:04:26Z
dc.date.available2018-03-29T01:04:26Z
dc.identifierInternational Urogynecology Journal And Pelvic Floor Dysfunction. v. 18, n. 10, p. 1185-90, 2007-Oct.
dc.identifier
dc.identifier10.1007/s00192-006-0294-4
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17347794
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197193
dc.identifier17347794
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297426
dc.descriptionThe authors quantified the type IV collagen fibers volumetric density in the basement membrane of bladder wall of ovariectomized rats with and without estradiol replacement. This study was conducted on 40 Wistar rats (3 months old) randomly divided in 4 groups: group 1, remained intact (control); group 2, submitted to bilateral oophorectomy and daily replacement 4 weeks later of 17 beta-estradiol for 12 weeks; group 3, sham operated and daily replacement 4 weeks later of sesame oil for 12 weeks; and group 4, submitted to bilateral oophorectomy and killed after 12 weeks. It was used in immunohistochemistry evaluation using type IV collagen polyclonal antibody to stain the fibers on paraffin rat bladder sections. The M-42 stereological grid system was used to analyze the fibers. Ovariectomy had an increase effect on the volumetric density of the type IV collagen fibers in the basement membrane of rat bladder wall. Estradiol replacement in castrated animals demonstrated a significative difference in the stereological parameters when compared to the castrated group without hormonal replacement. Surgical castration performed on rats induced an increasing volumetric density of type IV collagen fibers in the basement membrane of rats bladder wall and the estradiol treatment had a significant effect in keeping a low volumetric density of type IV collagen fibers in the basement membrane of rats bladder wall.
dc.description18
dc.description1185-90
dc.languageeng
dc.relationInternational Urogynecology Journal And Pelvic Floor Dysfunction
dc.relationInt Urogynecol J Pelvic Floor Dysfunct
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBasement Membrane
dc.subjectCollagen Type Iv
dc.subjectEstradiol
dc.subjectFemale
dc.subjectImmunohistochemistry
dc.subjectOvariectomy
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectUrinary Bladder
dc.titleRole Of 17 Beta-estradiol On Type Iv Collagen Fibers Volumetric Density In The Basement Membrane Of Bladder Wall.
dc.typeArtículos de revistas


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