Dual Mechanism Of Mangiferin Protection Against Iron-induced Damage To 2-deoxyribose And Ascorbate Oxidation.

dc.creatorPardo-Andreu, Gilberto Lázaro
dc.creatorDelgado, René
dc.creatorNúñez-Sellés, Alberto J
dc.creatorVercesi, Anibal E
dc.date2006-Mar
dc.date2015-11-27T13:06:15Z
dc.date2015-11-27T13:06:15Z
dc.date.accessioned2018-03-29T01:04:12Z
dc.date.available2018-03-29T01:04:12Z
dc.identifierPharmacological Research : The Official Journal Of The Italian Pharmacological Society. v. 53, n. 3, p. 253-60, 2006-Mar.
dc.identifier1043-6618
dc.identifier10.1016/j.phrs.2005.06.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16412661
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197126
dc.identifier16412661
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297359
dc.descriptionWe studied mangiferin effects on the degradation of 2-deoxyribose induced by Fe(III)-EDTA/citrate plus ascorbate, in relation to ascorbate oxidation (measured at 265 nm). Results revealed that mangiferin was equally effective in preventing degradation of both 15 and 1.5 mM 2-deoxyribose. At a fixed Fe(III) concentration, increasing the concentration of ligands (either EDTA or citrate) caused a significant reduction in the protective effects of mangiferin. Interestingly, mangiferin strongly stimulated Fe(III)-EDTA ascorbate oxidation, but inhibited it when citrate was used as iron co-chelator. Mangiferin stimulated O2 consumption due to Fe(II) (formed by Fe(III) ascorbate reduction) autoxidation when the metal ligand was EDTA, but inhibited it when citrate was used. These results suggest that mangiferin removes iron from citrate, but not from EDTA, forming an iron-mangiferin complex that cannot induce ascorbate oxidation effectively, thus inhibiting iron-mediated oxyradical formation. Taken together, these results indicate that mangiferin works mainly by a mechanism different from the classical hydroxyl radical scavengers, keeping iron in its ferric form, by complexing Fe(III), or stimulating Fe(II) autoxidation.
dc.description53
dc.description253-60
dc.languageeng
dc.relationPharmacological Research : The Official Journal Of The Italian Pharmacological Society
dc.relationPharmacol. Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAntioxidants
dc.subjectAscorbic Acid
dc.subjectDeoxyribose
dc.subjectEdetic Acid
dc.subjectFerric Compounds
dc.subjectIron Chelating Agents
dc.subjectModels, Chemical
dc.subjectOxidation-reduction
dc.subjectXanthones
dc.titleDual Mechanism Of Mangiferin Protection Against Iron-induced Damage To 2-deoxyribose And Ascorbate Oxidation.
dc.typeArtículos de revistas


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