Euphorbia Tirucalli L. Modulates Myelopoiesis And Enhances The Resistance Of Tumour-bearing Mice.

dc.creatorValadares, Marize C
dc.creatorCarrucha, Silvia Granja
dc.creatorAccorsi, Walter
dc.creatorQueiroz, Mary L S
dc.date2006-Feb
dc.date2015-11-27T13:06:13Z
dc.date2015-11-27T13:06:13Z
dc.date.accessioned2018-03-29T01:04:06Z
dc.date.available2018-03-29T01:04:06Z
dc.identifierInternational Immunopharmacology. v. 6, n. 2, p. 294-9, 2006-Feb.
dc.identifier1567-5769
dc.identifier10.1016/j.intimp.2005.07.013
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16399635
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197103
dc.identifier16399635
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297336
dc.descriptionMyelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses. The changes produced by the tumour in total and differential marrow cell counts were restored by the treatment with ET. Prostaglandin E2 (PGE2) levels, which were dramatically increased in tumour bearers, was also abrogated by the treatment with the plant extract. Euphorbia tirucalli L. significantly enhanced survival and concurrently reduced tumour growth in the peritoneal cavity. We propose that the modulatory effect of Euphorbia tirucalli L. on myelopoietic response and on the levels of PGE2 may be related to its antitumour activity as a possible mechanism for the regulation of granulocyte and macrophage production and expression of functional activities.
dc.description6
dc.description294-9
dc.languageeng
dc.relationInternational Immunopharmacology
dc.relationInt. Immunopharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectBone Marrow Cells
dc.subjectCarcinoma, Ehrlich Tumor
dc.subjectDinoprostone
dc.subjectEuphorbia
dc.subjectHematopoiesis
dc.subjectHematopoietic Stem Cells
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMyelopoiesis
dc.subjectNeoplastic Stem Cells
dc.subjectPlant Extracts
dc.subjectSpleen
dc.subjectSurvival Analysis
dc.titleEuphorbia Tirucalli L. Modulates Myelopoiesis And Enhances The Resistance Of Tumour-bearing Mice.
dc.typeArtículos de revistas


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