Phylogenetic Relationships Of Brazilian Bovine Respiratory Syncytial Virus Isolates And Molecular Homology Modeling Of Attachment Glycoprotein.

dc.creatorSpilki, Fernando Rosado
dc.creatorAlmeida, Renata Servan
dc.creatorDomingues, Helena Gallichio
dc.creatorD'Arce, Regina Celia Freitas
dc.creatorFerreira, Helena Lage
dc.creatorCampalans, Jaqueline
dc.creatorCosta, Sandra Cecília Botelho
dc.creatorArns, Clarice Weis
dc.date2006-Mar
dc.date2015-11-27T13:06:06Z
dc.date2015-11-27T13:06:06Z
dc.date.accessioned2018-03-29T01:03:54Z
dc.date.available2018-03-29T01:03:54Z
dc.identifierVirus Research. v. 116, n. 1-2, p. 30-7, 2006-Mar.
dc.identifier0168-1702
dc.identifier10.1016/j.virusres.2005.08.010
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16387381
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197048
dc.identifier16387381
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297281
dc.descriptionBovine respiratory syncytial virus (BRSV) causes lower respiratory tract disease in young cattle. Recently, it was possible to determine the sequence of the G protein gene, which plays a role in the attachment of BRSV particles to the cells, from three distinct Brazilian isolates. The phylogenetic analysis conducted here using those sequences compared to other worldwide distributed isolates of BRSV allow us to allocate Brazilian strains within the subgroup B, which was no longer found in the world since the 1970s. One of the Brazilian strains has a major mutation between amino acid residues 173 and 178, within the central hydrophobic conserved region, exactly on the site of two of the four cysteine-noose forming cysteine residues. Homology modeling with the previously determined NMR structure of this protein domain was made to check whether these mutations altered the three-dimensional conformation of this immunodominant region. Possible consequences on the biological effects induced by such mutation on the G protein are discussed.
dc.description116
dc.description30-7
dc.languageeng
dc.relationVirus Research
dc.relationVirus Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectBrazil
dc.subjectCattle
dc.subjectComputational Biology
dc.subjectModels, Molecular
dc.subjectMolecular Sequence Data
dc.subjectMutation
dc.subjectPhylogeny
dc.subjectProtein Structure, Tertiary
dc.subjectRespiratory Syncytial Virus Infections
dc.subjectRespiratory Syncytial Virus, Bovine
dc.subjectSequence Homology, Amino Acid
dc.subjectViral Envelope Proteins
dc.titlePhylogenetic Relationships Of Brazilian Bovine Respiratory Syncytial Virus Isolates And Molecular Homology Modeling Of Attachment Glycoprotein.
dc.typeArtículos de revistas


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