Styryl Lactones And Their Derivatives: Biological Activities, Mechanisms Of Action And Potential Leads For Drug Design.

dc.creatorde Fátima, A
dc.creatorModolo, L V
dc.creatorConegero, L S
dc.creatorPilli, R A
dc.creatorFerreira, C V
dc.creatorKohn, L K
dc.creatorde Carvalho, J E
dc.date2006
dc.date2015-11-27T13:06:06Z
dc.date2015-11-27T13:06:06Z
dc.date.accessioned2018-03-29T01:03:54Z
dc.date.available2018-03-29T01:03:54Z
dc.identifierCurrent Medicinal Chemistry. v. 13, n. 28, p. 3371-84, 2006.
dc.identifier0929-8673
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17168711
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197047
dc.identifier17168711
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297280
dc.descriptionNature is an inexhaustible source of natural compounds with interesting biological activities. In general, natural products are an important source of new compounds with a variety of structural arrangements and singular properties. Styryl lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess interesting biological properties, in particular antiproliferative activity against cancer cells. In general, the cytotoxicity of styryl lactones appears to be specific against cancer cells since insignificant effects of these compounds on normal cells are reported. A large body of evidence suggests that the antiproliferative activity of styryl lactones is associated with the induction of apoptosis in target cells. In the first part of this review we discuss the biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis. Stru described in detail for ninety styryl lactones. The last part describes the molecular targets of styryl lactones for inducing apoptosis, as well as immunosuppressive and inflammatory processes. Overall, understanding how these compounds exert their activities in biological system is essential for future development and application of styryl lactones for human health.
dc.description13
dc.description3371-84
dc.languageeng
dc.relationCurrent Medicinal Chemistry
dc.relationCurr. Med. Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectCell Line, Tumor
dc.subjectDrug Design
dc.subjectHumans
dc.subjectLactones
dc.subjectStructure-activity Relationship
dc.titleStyryl Lactones And Their Derivatives: Biological Activities, Mechanisms Of Action And Potential Leads For Drug Design.
dc.typeArtículos de revistas


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