In Vitro Studies On The Release Of Isoniazid Incorporated In Poly(epsilon-caprolactone).

dc.creatorDurán, N
dc.creatorDe Oliveira, A F
dc.creatorDe Azevedo, M M M
dc.date2006-Oct
dc.date2015-11-27T13:06:03Z
dc.date2015-11-27T13:06:03Z
dc.date.accessioned2018-03-29T01:03:48Z
dc.date.available2018-03-29T01:03:48Z
dc.identifierJournal Of Chemotherapy (florence, Italy). v. 18, n. 5, p. 473-9, 2006-Oct.
dc.identifier1120-009X
dc.identifier10.1179/joc.2006.18.5.473
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17127222
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197024
dc.identifier17127222
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297257
dc.descriptionA polymeric micro- and nanosphere formulation using poly (epsilon-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.
dc.description18
dc.description473-9
dc.languageeng
dc.relationJournal Of Chemotherapy (florence, Italy)
dc.relationJ Chemother
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntibiotics, Antitubercular
dc.subjectArtemia
dc.subjectCaproates
dc.subjectDelayed-action Preparations
dc.subjectDrug Compounding
dc.subjectDrug Delivery Systems
dc.subjectIsoniazid
dc.subjectLactones
dc.subjectMicrospheres
dc.subjectNanotubes
dc.subjectParticle Size
dc.subjectPolymers
dc.subjectToxicity Tests
dc.titleIn Vitro Studies On The Release Of Isoniazid Incorporated In Poly(epsilon-caprolactone).
dc.typeArtículos de revistas


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