Tissue Evidence Of The Testosterone Role On The Abnormal Growth And Aging Effects Reversion In The Gerbil (meriones Unguiculatus) Prostate.

dc.creatorScarano, Wellerson Rodrigo
dc.creatorVilamaior, Patricia Simone Leite
dc.creatorTaboga, Sebastião Roberto
dc.date2006-Nov
dc.date2015-11-27T13:05:55Z
dc.date2015-11-27T13:05:55Z
dc.date.accessioned2018-03-29T01:03:35Z
dc.date.available2018-03-29T01:03:35Z
dc.identifierThe Anatomical Record. Part A, Discoveries In Molecular, Cellular, And Evolutionary Biology. v. 288, n. 11, p. 1190-200, 2006-Nov.
dc.identifier1552-4884
dc.identifier10.1002/ar.a.20391
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17031809
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196969
dc.identifier17031809
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297202
dc.descriptionProstate differentiation during embryogenesis and its further homeostatic state maintenance during adult life depend on androgens. Abundant biological data suggest that androgens play an important role in the development of the prostate cancer and other prostatic diseases. The objective of this work was to evaluate the effects of the testosterone supplementation in gerbil (a new experimental model) at different ages. Tissues from experimental animals were studied by histological and histochemistry procedures, androgen receptor immunohistochemistry assay, morphometric-stereological analysis, and transmission electron microscopy (TEM). After the treatment were observed increase of prostate weight and epithelium height in all ages studied. In some adult and aged treated animals, hyperplasic and dysplastic process were observed, including prostatic intraepithelial neoplasias and adenocarcinomas. Increase of the thickness of the smooth muscle cell (SMC) layer was observed in pubescent and adult animals and TEM revealed apparent SMC hypertrophy. An apparent increase in the frequency of blood vessels distributed by the subepithelial stroma in the treated animals was noticed. Reversion of the natural effects of aging on the prostate was observed in the aged treated animals in some acini of the gland. These data demonstrate that the gerbil prostate is susceptible to androgenic action at the studied ages and it can serve, for example, as experimental model to studies of prostate neoplastic process induction and hormonal therapy in aged animals.
dc.description288
dc.description1190-200
dc.languageeng
dc.relationThe Anatomical Record. Part A, Discoveries In Molecular, Cellular, And Evolutionary Biology
dc.relationAnat Rec A Discov Mol Cell Evol Biol
dc.rightsfechado
dc.rights(c) 2006 Wiley-Liss, Inc.
dc.sourcePubMed
dc.subjectAge Factors
dc.subjectAging
dc.subjectAndrogens
dc.subjectAnimals
dc.subjectCell Proliferation
dc.subjectDisease Models, Animal
dc.subjectEpithelial Cells
dc.subjectGerbillinae
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMicroscopy, Electron, Transmission
dc.subjectMyocytes, Smooth Muscle
dc.subjectOrgan Size
dc.subjectProstate
dc.subjectProstatic Hyperplasia
dc.subjectProstatic Intraepithelial Neoplasia
dc.subjectProstatic Neoplasms
dc.subjectReceptors, Androgen
dc.subjectTestosterone
dc.titleTissue Evidence Of The Testosterone Role On The Abnormal Growth And Aging Effects Reversion In The Gerbil (meriones Unguiculatus) Prostate.
dc.typeArtículos de revistas


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