dc.creatorFerreira, J H T
dc.creatorTerzi, R G G
dc.creatorPaschoal, I A
dc.creatorSilva, W A
dc.creatorMoraes, A C
dc.creatorMoreira, M M
dc.date2006-Sep
dc.date2015-11-27T13:05:51Z
dc.date2015-11-27T13:05:51Z
dc.date.accessioned2018-03-29T01:03:30Z
dc.date.available2018-03-29T01:03:30Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 39, n. 9, p. 1197-204, 2006-Sep.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16981047
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196945
dc.identifier16981047
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297178
dc.descriptionThe aim of the present study was to determine the ventilation/perfusion ratio that contributes to hypoxemia in pulmonary embolism by analyzing blood gases and volumetric capnography in a model of experimental acute pulmonary embolism. Pulmonary embolization with autologous blood clots was induced in seven pigs weighing 24.00 +/- 0.6 kg, anesthetized and mechanically ventilated. Significant changes occurred from baseline to 20 min after embolization, such as reduction in oxygen partial pressures in arterial blood (from 87.71 +/- 8.64 to 39.14 +/- 6.77 mmHg) and alveolar air (from 92.97 +/- 2.14 to 63.91 +/- 8.27 mmHg). The effective alveolar ventilation exhibited a significant reduction (from 199.62 +/- 42.01 to 84.34 +/- 44.13) consistent with the fall in alveolar gas volume that effectively participated in gas exchange. The relation between the alveolar ventilation that effectively participated in gas exchange and cardiac output (V Aeff/Q ratio) also presented a significant reduction after embolization (from 0.96 +/- 0.34 to 0.33 +/- 0.17 fraction). The carbon dioxide partial pressure increased significantly in arterial blood (from 37.51 +/- 1.71 to 60.76 +/- 6.62 mmHg), but decreased significantly in exhaled air at the end of the respiratory cycle (from 35.57 +/- 1.22 to 23.15 +/- 8.24 mmHg). Exhaled air at the end of the respiratory cycle returned to baseline values 40 min after embolism. The arterial to alveolar carbon dioxide gradient increased significantly (from 1.94 +/- 1.36 to 37.61 +/- 12.79 mmHg), as also did the calculated alveolar (from 56.38 +/- 22.47 to 178.09 +/- 37.46 mL) and physiological (from 0.37 +/- 0.05 to 0.75 +/- 0.10 fraction) dead spaces. Based on our data, we conclude that the severe arterial hypoxemia observed in this experimental model may be attributed to the reduction of the V Aeff/Q ratio. We were also able to demonstrate that V Aeff/Q progressively improves after embolization, a fact attributed to the alveolar ventilation redistribution induced by hypocapnic bronchoconstriction.
dc.description39
dc.description1197-204
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectAnimals
dc.subjectAnoxia
dc.subjectDisease Models, Animal
dc.subjectOxygen Consumption
dc.subjectPulmonary Alveoli
dc.subjectPulmonary Embolism
dc.subjectPulmonary Gas Exchange
dc.subjectSwine
dc.titleMechanisms Underlying Gas Exchange Alterations In An Experimental Model Of Pulmonary Embolism.
dc.typeArtículos de revistas


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