Circulating Ghrelin Concentrations Are Lowered By Intracerebroventricular Insulin.

dc.creatorUeno, M
dc.creatorCarvalheira, J B C
dc.creatorOliveira, R L G S
dc.creatorVelloso, L A
dc.creatorSaad, M J A
dc.date2006-Oct
dc.date2015-11-27T13:05:47Z
dc.date2015-11-27T13:05:47Z
dc.date.accessioned2018-03-29T01:03:25Z
dc.date.available2018-03-29T01:03:25Z
dc.identifierDiabetologia. v. 49, n. 10, p. 2449-52, 2006-Oct.
dc.identifier0012-186X
dc.identifier10.1007/s00125-006-0371-8
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16955211
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196923
dc.identifier16955211
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297156
dc.descriptionGhrelin is a peptide that is mainly produced by the stomach and stimulates food intake, adiposity and weight gain. Previous studies have documented that plasma levels of ghrelin are reduced by insulin, but the mechanisms that mediate this effect are unclear. To determine whether phosphatidylinositol 3-kinase (PI(3)K) and/or mitogen-activated protein kinase (MAPK) are involved in this insulin action, we tested the intracerebroventricular (i.c.v.) effect of specific inhibitors of PI(3)K (LY294002 and wortmannin) and MAPK (PD98059 and UO126) on the insulin-mediated reduction of ghrelin levels in rats. Intracerebroventricular treatment with insulin reduced ghrelin levels. Inhibition of PI(3)K specifically blocked the insulin-induced reduction in ghrelin concentration, whereas inhibition of MAPK had no effect on insulin-mediated actions. Moreover, pretreatment with i.c.v. PI(3)K inhibitors blocked the reduction of ghrelin levels after OGTT-induced hyperglycaemia and hyperinsulinaemia. These data demonstrate that changes in insulin action in the central nervous system regulate circulating ghrelin levels and that PI(3)K is a specific mediator of this action.
dc.description49
dc.description2449-52
dc.languageeng
dc.relationDiabetologia
dc.relationDiabetologia
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectFood Deprivation
dc.subjectGhrelin
dc.subjectHypothalamus
dc.subjectInjections, Intraventricular
dc.subjectInsulin
dc.subjectKinetics
dc.subjectMitogen-activated Protein Kinases
dc.subjectPeptide Hormones
dc.subjectPhosphatidylinositol 3-kinases
dc.subjectRats
dc.titleCirculating Ghrelin Concentrations Are Lowered By Intracerebroventricular Insulin.
dc.typeArtículos de revistas


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