Polymorphisms At Exon 4 Of P53 And The Susceptibility To Herpesvirus Types 6 And 1 Infection In Renal Transplant Recipients.

dc.creatorLeite, Janaína L
dc.creatorManfrinatto, Juliana A
dc.creatorMazzali, Marilda
dc.creatorWard, Laura S
dc.date2006-Sep
dc.date2015-11-27T13:05:42Z
dc.date2015-11-27T13:05:42Z
dc.date.accessioned2018-03-29T01:03:16Z
dc.date.available2018-03-29T01:03:16Z
dc.identifierTransplant International : Official Journal Of The European Society For Organ Transplantation. v. 19, n. 9, p. 732-7, 2006-Sep.
dc.identifier0934-0874
dc.identifier10.1111/j.1432-2277.2006.00346.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16918534
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196890
dc.identifier16918534
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297123
dc.descriptionIn order to replicate their own genome in the host nucleus, herpesviruses have to overcome the barrier presented by p53 gene. Variants of codon 72 and codon 47 of exon four decrease the ability of p53 to induce apoptosis. In order to investigate the influence of this germline inheritance on the susceptibility to herpesvirus type 6 (HHV6) and 1 (HHV1) infection, we examined 78 renal transplant recipients and 151 controls. HHV6 infection was more frequent among the renal transplant patients (35.89%) than in the control population (11.25%) (P < 0.001). HHV1 infection rate was similar in renal transplant patients (7.28%) and controls (2.56%). HHV6-positive cases were more frequent among patients with codon 72 of p53 variants (60.71%) than among wild-type p53 patients (28.20%) (P = 0.001) despite the higher frequency of codon 72 of p53 wild-type variant in renal transplant patients compared with controls (64.1% vs. 36.4%; P < 0.001). The presence of a codon 72 of p53 germline variant genotype increased the risk for HHV6 infection more than five times (OR = 5.479; 95% CI = 1.992-15.069). Our data suggest that codon 72 of p53 polymorphism genotyping may be useful to screen for patients at higher risk for post-transplant infections hence identifying individuals that could benefit from preventive treatment.
dc.description19
dc.description732-7
dc.languageeng
dc.relationTransplant International : Official Journal Of The European Society For Organ Transplantation
dc.relationTranspl. Int.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectExons
dc.subjectFemale
dc.subjectGenetic Predisposition To Disease
dc.subjectGraft Rejection
dc.subjectHerpes Simplex
dc.subjectHerpesvirus 1, Human
dc.subjectHerpesvirus 6, Human
dc.subjectHumans
dc.subjectImmunosuppression
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Genetic
dc.subjectPostoperative Complications
dc.subjectRisk Factors
dc.subjectRoseolovirus Infections
dc.subjectTumor Suppressor Protein P53
dc.titlePolymorphisms At Exon 4 Of P53 And The Susceptibility To Herpesvirus Types 6 And 1 Infection In Renal Transplant Recipients.
dc.typeArtículos de revistas


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