The Scn2a Gene Is Not A Likely Candidate For Familial Mesial Temporal Lobe Epilepsy.

dc.creatorMaurer-Morelli, Cláudia Vianna
dc.creatorSecolin, Rodrigo
dc.creatorMarchesini, Rafael Breglio
dc.creatorSantos, Neide Ferreira
dc.creatorKobayashi, Eliane
dc.creatorCendes, Fernando
dc.creatorLopes-Cendes, Iscia
dc.date2006-Oct
dc.date2015-11-27T13:05:41Z
dc.date2015-11-27T13:05:41Z
dc.date.accessioned2018-03-29T01:03:14Z
dc.date.available2018-03-29T01:03:14Z
dc.identifierEpilepsy Research. v. 71, n. 2-3, p. 233-6, 2006-Oct.
dc.identifier0920-1211
dc.identifier10.1016/j.eplepsyres.2006.06.016
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16914293
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196880
dc.identifier16914293
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297113
dc.descriptionA transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE.
dc.description71
dc.description233-6
dc.languageeng
dc.relationEpilepsy Research
dc.relationEpilepsy Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectEpilepsy, Temporal Lobe
dc.subjectGenetic Linkage
dc.subjectHumans
dc.subjectMicrosatellite Repeats
dc.subjectMutation
dc.subjectNav1.2 Voltage-gated Sodium Channel
dc.subjectNerve Tissue Proteins
dc.subjectSclerosis
dc.subjectSodium Channels
dc.subjectTemporal Lobe
dc.titleThe Scn2a Gene Is Not A Likely Candidate For Familial Mesial Temporal Lobe Epilepsy.
dc.typeArtículos de revistas


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