Acetylcholine Receptors And Nerve Terminal Distribution At The Neuromuscular Junction Of Long-term Regenerated Muscle Fibers.

dc.creatorMarques, Maria Julia
dc.creatorMendes, Zarif T R
dc.creatorMinatel, Elaine
dc.creatorSanto Neto, Humberto
dc.date2005-Dec
dc.date2015-11-27T13:05:40Z
dc.date2015-11-27T13:05:40Z
dc.date.accessioned2018-03-29T01:03:12Z
dc.date.available2018-03-29T01:03:12Z
dc.identifierJournal Of Neurocytology. v. 34, n. 6, p. 387-96, 2005-Dec.
dc.identifier0300-4864
dc.identifier10.1007/s11068-006-8725-1
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16902760
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196871
dc.identifier16902760
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297104
dc.descriptionMdx mice are deficient in dystrophin and show muscle fiber regeneration. Changes in the distribution of acetylcholine receptors have been reported at the neuromuscular junction of mdx mice and may be a consequence of muscle fiber regeneration. In this study, we examined whether the distribution of receptors was still altered in long-term, regenerated muscle fibers from C57Bl/10 mice. The left sternomastoid muscle of adult mice was injected with 60 microl of lidocaine hydrochloride to induce muscle degeneration-regeneration. In some mice, the sternomastoid muscle was denervated at the time of lidocaine injection. After 90 and 150 days, the nicotinic acetylcholine receptors were labeled with rhodamine-alpha-bungarotoxin for confocal microscopy. At both intervals studied, the receptors were distributed in spots. In denervated-regenerated fibers, the receptors were distributed as regular branches similar to denervated muscles without lidocaine treatment. These findings suggested that nerve-dependent mechanisms were involved in the changes in receptor distribution seen in regenerated muscle fibers after lidocaine treatment, and that a similar phenomenon could explain the changes in receptor distribution seen in dystrophic muscle fibers.
dc.description34
dc.description387-96
dc.languageeng
dc.relationJournal Of Neurocytology
dc.relationJ. Neurocytol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCytotoxins
dc.subjectDenervation
dc.subjectLidocaine
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMicroscopy, Confocal
dc.subjectMuscle Fibers, Skeletal
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophies
dc.subjectNeuromuscular Junction
dc.subjectPresynaptic Terminals
dc.subjectReceptors, Nicotinic
dc.subjectRegeneration
dc.subjectSynaptic Transmission
dc.subjectTime
dc.subjectTime Factors
dc.titleAcetylcholine Receptors And Nerve Terminal Distribution At The Neuromuscular Junction Of Long-term Regenerated Muscle Fibers.
dc.typeArtículos de revistas


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