Cancer During Pregnancy Alters The Activity Of Rat Placenta And Enhances The Expression Of Cleaved Parp, Cytochrome-c And Caspase 3.

dc.creatorToledo, Mércia Tancredo
dc.creatorVentrucci, Gislaine
dc.creatorMarcondes, Maria Cristina Cintra Gomes
dc.date2006
dc.date2015-11-27T13:05:34Z
dc.date2015-11-27T13:05:34Z
dc.date.accessioned2018-03-29T01:03:02Z
dc.date.available2018-03-29T01:03:02Z
dc.identifierBmc Cancer. v. 6, p. 168, 2006.
dc.identifier1471-2407
dc.identifier10.1186/1471-2407-6-168
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16800886
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196823
dc.identifier16800886
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297056
dc.descriptionThe presence of cancer makes it difficult to predict the progress of pregnancy and can be deleterious to the maternal-foetal relationship. Apoptosis may affect a range of placental functions and result in the retardation of foetal growth. In this work, we investigated the placental alterations produced by tumour growth and the effects on the expression of apoptotic factors in placental tissue. Adult female Wistar rats (90 days old, n = 54) were allocated to control (C), tumour-bearing (W), or ascitic fluid-injected (A) groups and were killed on the 16th, 19th or 21st day of pregnancy. Placental tissues were analysed using biochemical and histochemical assays. The placental protein content and glutathione-S-transferase activity were decreased in groups W and A. Histochemical analysis showed an increase in the number of cells with cleaved PARP, caspase 3 and cytochrome-c in groups W and A, indicating that the tumour growth clearly damaged placental tissue and affected the levels of apoptotic factors. These results were confirmed by western blotting. Since trophoblastic cells are responsible for maintaining a normal placental function, the uncontrolled death of these cells in response to tumour cell growth or substances derived from ascitic fluid could have a negative impact on foetal development. Further knowledge of these events may help to preserve the foetus and placenta during development.
dc.description6
dc.description168
dc.languageeng
dc.relationBmc Cancer
dc.relationBMC Cancer
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAscitic Fluid
dc.subjectCaspase 3
dc.subjectCell Line, Tumor
dc.subjectCytochromes C
dc.subjectFemale
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectNeoplasm Transplantation
dc.subjectNeoplasms
dc.subjectOrgan Size
dc.subjectPlacenta
dc.subjectPoly(adp-ribose) Polymerases
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Wistar
dc.titleCancer During Pregnancy Alters The Activity Of Rat Placenta And Enhances The Expression Of Cleaved Parp, Cytochrome-c And Caspase 3.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución