Pycnogenol Protects Against Ionizing Radiation As Shown In The Intestinal Mucosa Of Rats Exposed To X-rays.

dc.creatorde Moraes Ramos, Flávia Maria
dc.creatorSchönlau, Frank
dc.creatorNovaes, Pedro Duarte
dc.creatorManzi, Flávio Ricardo
dc.creatorBóscolo, Frab Norberto
dc.creatorde Almeida, Solange Maria
dc.date2006-Aug
dc.date2015-11-27T13:05:31Z
dc.date2015-11-27T13:05:31Z
dc.date.accessioned2018-03-29T01:02:55Z
dc.date.available2018-03-29T01:02:55Z
dc.identifierPhytotherapy Research : Ptr. v. 20, n. 8, p. 676-9, 2006-Aug.
dc.identifier0951-418X
dc.identifier10.1002/ptr.1934
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16752373
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196798
dc.identifier16752373
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297031
dc.descriptionX-rays and gamma radiation delivered to the abdominal region for cancer treatment encompasses severe damage to the intestinal mucosa, which significantly impairs a patient's quality of life. To a great extent the deleterious effects of x-radiation originate from radiolysis-induced reactive oxygen species. The well-researched powerful antioxidant Pycnogenol was administered orally to rats prior to x-irradiation with 15 Gy. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without Pycnogenol. Pycnogenol treatment significantly preserved the height and number of villi as well as the glandular layer and a diminished number of congested vases were present. No intestinal alterations were seen in control animals receiving Pycnogenol in the absence of radiation. It is concluded that Pycnogenol provides significant protection from ionizing radiation damage.
dc.description20
dc.description676-9
dc.languageeng
dc.relationPhytotherapy Research : Ptr
dc.relationPhytother Res
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdjuvants, Immunologic
dc.subjectAnimals
dc.subjectFlavonoids
dc.subjectFree Radical Scavengers
dc.subjectIntestinal Mucosa
dc.subjectMale
dc.subjectRadiation Injuries, Experimental
dc.subjectRadiation-protective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectX-rays
dc.titlePycnogenol Protects Against Ionizing Radiation As Shown In The Intestinal Mucosa Of Rats Exposed To X-rays.
dc.typeArtículos de revistas


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