Astrocyte Reactivity Influences The Number Of Presynaptic Terminals Apposed To Spinal Motoneurons After Axotomy.

dc.creatorEmirandetti, Amanda
dc.creatorGraciele Zanon, Renata
dc.creatorSabha, Mario
dc.creatorde Oliveira, Alexandre Leite Rodrigues
dc.date2006-Jun
dc.date2015-11-27T13:05:28Z
dc.date2015-11-27T13:05:28Z
dc.date.accessioned2018-03-29T01:02:51Z
dc.date.available2018-03-29T01:02:51Z
dc.identifierBrain Research. v. 1095, n. 1, p. 35-42, 2006-Jun.
dc.identifier0006-8993
dc.identifier10.1016/j.brainres.2006.04.021
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16714003
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196778
dc.identifier16714003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297011
dc.descriptionAlthough synaptic plasticity is a widespread phenomenon, the underlying mechanisms leading to its occurrence are virtually unknown. In this sense, glial cells, especially astrocytes, may have a role in network changes of the nervous system, influencing the retraction of boutons as well as providing a proper perisynaptic environment, thereby affecting the replacement of inputs. Interestingly, the glial reaction does vary between strains of rats and mice. In this sense, we present evidence that C57BL/6J and A/J isogenic mice present different astrocyte reactivity after a peripheral lesion in vivo as well as in vitro, by analyzing primary cell cultures. Such a difference in the glial reaction has a direct influence on in vivo number of pre-synaptic terminals and on in vitro synaptogenesis.
dc.description1095
dc.description35-42
dc.languageeng
dc.relationBrain Research
dc.relationBrain Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectAstrocytes
dc.subjectAxotomy
dc.subjectCells, Cultured
dc.subjectCerebral Cortex
dc.subjectCytoskeletal Proteins
dc.subjectFunctional Laterality
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectImmunohistochemistry
dc.subjectIndoles
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMotor Neurons
dc.subjectPresynaptic Terminals
dc.subjectSpinal Cord Injuries
dc.subjectStatistics, Nonparametric
dc.subjectSynaptophysin
dc.titleAstrocyte Reactivity Influences The Number Of Presynaptic Terminals Apposed To Spinal Motoneurons After Axotomy.
dc.typeArtículos de revistas


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