Nerve-terminal And Schwann-cell Response After Nerve Injury In The Absence Of Nitric Oxide.

dc.creatorMarques, Maria Julia
dc.creatorPereira, Elaine Cristina Leite
dc.creatorMinatel, Elaine
dc.creatorNeto, Humberto Santo
dc.date2006-Aug
dc.date2015-11-27T13:05:27Z
dc.date2015-11-27T13:05:27Z
dc.date.accessioned2018-03-29T01:02:49Z
dc.date.available2018-03-29T01:02:49Z
dc.identifierMuscle & Nerve. v. 34, n. 2, p. 225-31, 2006-Aug.
dc.identifier0148-639X
dc.identifier10.1002/mus.20576
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16708367
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196770
dc.identifier16708367
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297003
dc.descriptionDystrophic muscles show alterations in the dystrophin-glycoprotein complex and a lack of neuronal nitric oxide (NO) synthase. In mdx mice, presynaptic expression of neuronal NO synthase is decreased, suggesting that presynaptic signaling may be altered in dystrophic muscle. In this study, we examined the nerve-terminal and Schwann-cell responses after a crush lesion in control and NO-deficient mice. Seven days after nerve crush, 24% of control neuromuscular junctions (n = 200) showed ultraterminal sprouts, whereas in NO-deficient mice this frequency was 28.5% (n = 217; P > 0.05 compared to controls; chi-square test). Schwann-cell response did not change in the absence of NO, after a nerve lesion of 7-day duration. Fourteen days after the lesion, nerve terminals sprouted and Schwann cells showed an extensive network of processes away from the synaptic site in controls. In the absence of NO, there was a dramatic decrease in nerve-terminal sprouting and Schwann-cell processes failed to extend away from the endplate. These results show that NO is involved in the nerve-terminal and Schwann-cell response to nerve injury. They also suggest that presynaptic molecular signaling may be impaired in dystrophic muscles, and this could influence the innervation and survival of newly formed myofibers generated by cell-mediated therapies.
dc.description34
dc.description225-31
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBody Weight
dc.subjectBrain
dc.subjectEnzyme Inhibitors
dc.subjectFemale
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMicroscopy, Confocal
dc.subjectNg-nitroarginine Methyl Ester
dc.subjectNerve Crush
dc.subjectNerve Endings
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase Type I
dc.subjectOrgan Size
dc.subjectPeripheral Nerve Injuries
dc.subjectSchwann Cells
dc.titleNerve-terminal And Schwann-cell Response After Nerve Injury In The Absence Of Nitric Oxide.
dc.typeArtículos de revistas


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