Vaginal Safety After Use Of A Bioadhesive, Acid-buffering, Microbicidal Contraceptive Gel (acidform) And A 2% Nonoxynol-9 Product.

dc.creatorAmaral, Eliana
dc.creatorPerdigao, Antero
dc.creatorSouza, Maria Helena
dc.creatorMauck, Christine
dc.creatorWaller, Donald
dc.creatorZaneveld, Lourens
dc.creatorFaundes, Anibal
dc.date2006-May
dc.date2015-11-27T13:05:22Z
dc.date2015-11-27T13:05:22Z
dc.date.accessioned2018-03-29T01:02:40Z
dc.date.available2018-03-29T01:02:40Z
dc.identifierContraception. v. 73, n. 5, p. 542-7, 2006-May.
dc.identifier0010-7824
dc.identifier10.1016/j.contraception.2005.12.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16627043
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196731
dc.identifier16627043
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296964
dc.descriptionACIDFORM is a microbicidal and contraceptive candidate with strong buffering capacity. This was a Phase I blinded, randomized and crossover clinical study on two products, ACIDFORM and a commercial nonoxynol-9 (N-9) product (2%), evaluating their vaginal safety in 20 couples aged between 19 and 45 years. The women had regular menses, underwent previous tubal ligation, were not breast-feeding, had no vaginal sign and symptom and were in a stable partnership; both partners had no previous STI. Colposcopy, vaginal microbiology, inflammation markers and subject complaints were studied after coitus. Women were randomly assigned sequentially to receive ACIDFORM 0-30 min (0-30 min before intercourse), ACIDFORM 8-10 h (8-10 h before intercourse) or N-9 0-30 min after a control cycle. Mild/moderate vulvar irritation was observed in five postcoital test colposcopies, burning and pruritus were reported in six treated cycles and non-irritation-related symptoms were found in five cycles with different treatments. No difference in vaginal pH, Nugent scores, H2O2-producing lactobacillus or leukocytes and interleukin 6 in the cervicovaginal lavage was found between the treatment and control cycles. ACIDFORM appears to be safe for clinical use once a day. There is a potential spermicidal-microbicidal role for ACIDFORM as a vaginal flora helper or as a vehicle for products, except N-9.
dc.description73
dc.description542-7
dc.languageeng
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAnti-infective Agents, Local
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrogen-ion Concentration
dc.subjectMale
dc.subjectNonoxynol
dc.subjectSpermatocidal Agents
dc.subjectVagina
dc.titleVaginal Safety After Use Of A Bioadhesive, Acid-buffering, Microbicidal Contraceptive Gel (acidform) And A 2% Nonoxynol-9 Product.
dc.typeArtículos de revistas


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