Cytotoxic Activity Of (s)-goniothalamin And Analogues Against Human Cancer Cells.

dc.creatorFátima, Angelo de
dc.creatorKohn, Luciana K
dc.creatorCarvalho, João Ernesto de
dc.creatorPilli, Ronaldo A
dc.date2006-Feb
dc.date2015-11-27T13:05:11Z
dc.date2015-11-27T13:05:11Z
dc.date.accessioned2018-03-29T01:02:22Z
dc.date.available2018-03-29T01:02:22Z
dc.identifierBioorganic & Medicinal Chemistry. v. 14, n. 3, p. 622-31, 2006-Feb.
dc.identifier0968-0896
dc.identifier10.1016/j.bmc.2005.08.036
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16202605
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196652
dc.identifier16202605
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296885
dc.description(R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) allowed us to establish the relevant structural features for the cytotoxic activity of goniothalamin analogues. In addition, we have identified non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth (786-0) with IC50 = 4 and 5 nM, respectively, and compound 8 (IC50 = 4 nM) as the more potent against breast cancer cells with resistance phenotype for adryamycin (NCI.ADR).
dc.description14
dc.description622-31
dc.languageeng
dc.relationBioorganic & Medicinal Chemistry
dc.relationBioorg. Med. Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAntineoplastic Agents
dc.subjectBreast Neoplasms
dc.subjectCell Line, Tumor
dc.subjectDoxorubicin
dc.subjectDrug Resistance, Neoplasm
dc.subjectFemale
dc.subjectHumans
dc.subjectKidney Neoplasms
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMale
dc.subjectNeoplasms
dc.subjectPyrones
dc.subjectStereoisomerism
dc.subjectStructure-activity Relationship
dc.titleCytotoxic Activity Of (s)-goniothalamin And Analogues Against Human Cancer Cells.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución