Nociception- And Anxiety-like Behavior In Rats Submitted To Different Periods Of Restraint Stress.

dc.creatorGameiro, Gustavo Hauber
dc.creatorGameiro, Paula Hauber
dc.creatorAndrade, Annicele da Silva
dc.creatorPereira, Lígia Ferrinho
dc.creatorArthuri, Mariana Trevisani
dc.creatorMarcondes, Fernanda Klein
dc.creatorVeiga, Maria Cecília Ferraz de Arruda
dc.date2006-Apr
dc.date2015-11-27T13:05:10Z
dc.date2015-11-27T13:05:10Z
dc.date.accessioned2018-03-29T01:02:20Z
dc.date.available2018-03-29T01:02:20Z
dc.identifierPhysiology & Behavior. v. 87, n. 4, p. 643-9, 2006-Apr.
dc.identifier0031-9384
dc.identifier10.1016/j.physbeh.2005.12.007
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16488452
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196645
dc.identifier16488452
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296878
dc.descriptionThe aim of this study was to evaluate the effect of acute, sub-chronic and chronic stress on nociception induced by formalin injection in rats' temporomandibular joint (TMJ). It was evaluated the relation between blood levels of adrenocorticotropin, corticosterone, the levels of anxiety and nociceptive responses recorded after different stress protocols. Animals were initially submitted to acute restraint stress (15; 30 min and 1 h), or exposed to sub-chronic (3 days-1 h/day) or chronic stress (40 days-1 h/day). Then, animals were (1) killed immediately to collect blood for hormonal determinations; or (2) submitted to the elevated plus-maze to evaluate anxiety; or (3) submitted to the TMJ formalin test to evaluate nociception. It was also evaluated the role of serotoninergic and opioid systems in nociceptive changes induced by stress. For this, the serotonin-selective reuptake inhibitor (fluoxetine 10 mg/kg) and the opioid agonist (morphine 1-5 mg/kg) were administered before the nociception test. All stress protocols significantly raised the levels of ACTH or corticosterone, as well as the anxiety behavior. In relation to nociception, the chronic stressed animals showed an increase in nociceptive responses (hyperalgesia). In this group, there was a reduction in the morphine analgesic effects, suggesting dysfunction in the endogenous opioid system. Fluoxetine had an analgesic effect in both stressed and control groups, although this effect was more evident in the stressed group. It was concluded that stress-induced hyperalgesia may result from changes in the serotoninergic and opioid systems, which can explain, at least in part, the important link between stress and orofacial pain.
dc.description87
dc.description643-9
dc.languageeng
dc.relationPhysiology & Behavior
dc.relationPhysiol. Behav.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnalgesics, Opioid
dc.subjectAnimals
dc.subjectAnxiety
dc.subjectChronic Disease
dc.subjectCortisone
dc.subjectDisease Models, Animal
dc.subjectEmotions
dc.subjectExploratory Behavior
dc.subjectFluoxetine
dc.subjectMale
dc.subjectMorphine
dc.subjectPain
dc.subjectPain Threshold
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Opioid
dc.subjectRestraint, Physical
dc.subjectSerotonin Uptake Inhibitors
dc.subjectStress, Psychological
dc.subjectTime Factors
dc.titleNociception- And Anxiety-like Behavior In Rats Submitted To Different Periods Of Restraint Stress.
dc.typeArtículos de revistas


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