Abnormal Production Of Transforming Growth Factor Beta And Interferon Gamma By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil.

dc.creatorCastro, Analia Z
dc.creatorDiaz-Bardalez, Blanca M
dc.creatorOliveira, Elaine C
dc.creatorGarcia, Reinaldo C
dc.creatorAfiune, Jorge Barros
dc.creatorPaschoal, Ilma A
dc.creatorSantos, Leonilda M B
dc.date2005-Nov
dc.date2015-11-27T13:02:35Z
dc.date2015-11-27T13:02:35Z
dc.date.accessioned2018-03-29T01:01:43Z
dc.date.available2018-03-29T01:01:43Z
dc.identifierThe Journal Of Infection. v. 51, n. 4, p. 318-24, 2005-Nov.
dc.identifier1532-2742
dc.identifier10.1016/j.jinf.2004.08.035
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16291285
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196489
dc.identifier16291285
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296722
dc.descriptionThe aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNgamma and normal production of transforming growth factor (TGFbeta), while MDR patients revealed a normal production of IFNgamma accompanied by an increase in TGFbeta. The production of significant amounts of TGFbeta in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs.
dc.description51
dc.description318-24
dc.languageeng
dc.relationThe Journal Of Infection
dc.relationJ. Infect.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectBrazil
dc.subjectCase-control Studies
dc.subjectDrug Resistance, Multiple
dc.subjectEnzyme-linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunity, Cellular
dc.subjectInterferon-gamma
dc.subjectLeukocytes, Mononuclear
dc.subjectLymphocyte Activation
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMitogens
dc.subjectMycobacterium Tuberculosis
dc.subjectTransforming Growth Factor Beta
dc.subjectTuberculin
dc.subjectTuberculosis, Pulmonary
dc.titleAbnormal Production Of Transforming Growth Factor Beta And Interferon Gamma By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil.
dc.typeArtículos de revistas


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