Genomic Structure And Regulation Of Mitochondrial Uncoupling Protein Genes In Mammals And Plants.

dc.creatorNogueira, Fábio T S
dc.creatorBorecký, Jiri
dc.creatorVercesi, Aníbal E
dc.creatorArruda, Paulo
dc.date
dc.date2015-11-27T13:02:34Z
dc.date2015-11-27T13:02:34Z
dc.date.accessioned2018-03-29T01:01:42Z
dc.date.available2018-03-29T01:01:42Z
dc.identifierBioscience Reports. v. 25, n. 3-4, p. 209-26
dc.identifier0144-8463
dc.identifier10.1007/s10540-005-2886-5
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16283554
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196485
dc.identifier16283554
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296718
dc.descriptionUncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes, fungi, and protozoa. Mammalian UCPs and plant uncoupling proteins (PUMPs) form five distinct subfamilies. Only subfamily III contains both plant and animal uncoupling proteins, as well as UCPs from primitive eukaryotic organisms, which suggest that this group may represent an ancestral cluster from which other UCPs/PUMPs may have evolved. Genetic data indicate that UCPs/PUMPs are regulated at the transcriptional, post-transcriptional, and translational levels. Tissue/organ- and stress-specific gene expression suggests that UCPs/PUMPs are involved in the general balance of basic energy expenditure, protection against reactive oxygen species, and thermogenesis. Finally, the simultaneous occurrence of PUMP and alternative oxidase, another energy-dissipating system in plant mitochondria, raises the question of their response to biotic and abiotic stress at the transcriptional and functional levels.
dc.description25
dc.description209-26
dc.languageeng
dc.relationBioscience Reports
dc.relationBiosci. Rep.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCarrier Proteins
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectMembrane Proteins
dc.subjectMitochondrial Proteins
dc.subjectMolecular Sequence Data
dc.subjectMultigene Family
dc.subjectPhylogeny
dc.subjectPlant Proteins
dc.subjectProtein Isoforms
dc.subjectTranscription, Genetic
dc.titleGenomic Structure And Regulation Of Mitochondrial Uncoupling Protein Genes In Mammals And Plants.
dc.typeArtículos de revistas


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