dc.creatorBerti, Jairo A
dc.creatorSalerno, Alessandro G
dc.creatorBighetti, Eliete J B
dc.creatorCasquero, Andrea C
dc.creatorBoschero, Antonio C
dc.creatorOliveira, Helena C F
dc.date2005-Jan
dc.date2015-11-27T13:02:34Z
dc.date2015-11-27T13:02:34Z
dc.date.accessioned2018-03-29T01:01:41Z
dc.date.available2018-03-29T01:01:41Z
dc.identifierApmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. v. 113, n. 1, p. 37-44, 2005-Jan.
dc.identifier0903-4641
dc.identifier10.1111/j.1600-0463.2005.apm1130106.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15676013
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196480
dc.identifier15676013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296713
dc.descriptionThe role of CETP expression and diabetes in atherogenesis was investigated in mice with heterozygous disruption of the LDL receptor gene (LDLR1). LDLR1 mice with and without CETP expression were treated with streptozotocin (STZ) and maintained on a standard diet for one month before switching to an atherogenic diet for an additional month. STZ-sensitive mice had approximately 2.5-fold higher glycemia and 7.5- to 8.0-fold higher cholesterolemia. Factorial analysis of variance showed no significant effect of diabetes, CETP or diabetes-CETP interaction on the size of the atherosclerotic lesions. CETP expression in non-diabetic mice resulted in a 50% reduction in the area of the atherosclerotic lesions. Multiple regression analysis showed a positive and independent atherogenic effect of triglyceridemia in LDLR1 mice and of cholesterolemia in diabetic mice. Logistic analysis showed that elevated plasma cholesterol level significantly increased the risk of developing large lesion size (>75th percentile). In conclusion, CETP expression did not alter the lesion formation in response to diabetes, although it may be protective in the euglycemic state; the triglyceride level was an independent risk factor for LDL receptor-deficient mice but not for CETP-expressing mice; and elevated plasma cholesterol levels increased the risk of developing large atherosclerotic lesions, independently of CETP and diabetes.
dc.description113
dc.description37-44
dc.languageeng
dc.relationApmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
dc.relationAPMIS
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectArteriosclerosis
dc.subjectBlood Glucose
dc.subjectCarrier Proteins
dc.subjectCholesterol Ester Transfer Proteins
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Angiopathies
dc.subjectDiet, Atherogenic
dc.subjectGlycoproteins
dc.subjectLipids
dc.subjectMice
dc.subjectReceptors, Ldl
dc.subjectRegression Analysis
dc.titleEffects Of Diabetes And Cetp Expression On Diet-induced Atherosclerosis In Ldl Receptor-deficient Mice.
dc.typeArtículos de revistas


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