Characterization Of The Acute Pancreatitis Induced By Secretory Phospholipases A2 In Rats.

dc.creatorCamargo, Enilton A
dc.creatorEsquisatto, Laura C M
dc.creatorEsquisatto, Marcelo A
dc.creatorRibela, Maria Teresa C P
dc.creatorCintra, Adélia C
dc.creatorGiglio, José R
dc.creatorAntunes, Edson
dc.creatorLanducci, Elen C T
dc.date2005-Dec
dc.date2015-11-27T13:02:32Z
dc.date2015-11-27T13:02:32Z
dc.date.accessioned2018-03-29T01:01:39Z
dc.date.available2018-03-29T01:01:39Z
dc.identifierToxicon : Official Journal Of The International Society On Toxinology. v. 46, n. 8, p. 921-6, 2005-Dec.
dc.identifier0041-0101
dc.identifier10.1016/j.toxicon.2005.09.001
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16263148
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196470
dc.identifier16263148
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296703
dc.descriptionAcute pancreatitis (AP) is an inflammatory disease of the pancreas characterized by local inflammation and extrapancreatic effects such as lung injury. Secretory phospholipases A(2) (PLA(2)s) have been implicated in triggering AP, but their exact role to evoke AP is largely unknown. Therefore, we have tested the ability of sPLA(2)s to induce AP in rats, using venom sPLA(2)s with residual or high enzymatic activity (bothropstoxin-II and Naja mocambique mocambique venom PLA(2), respectively), as well as sPLA(2) devoid of catalytic activity (piratoxin-I). The injection of Naja m. mocambique venom PLA(2), bothropstoxin-II or piratoxin-I (300 microg/kg each) into the common bile duct increased significantly the pancreatic plasma extravasation and myeloperoxidase activity. The lung myeloperoxidase and serum amylase were also increased for all groups, although the Naja mocambique mocambique venom PLA(2) induced higher lung myeloperoxidase and serum amylase values, compared with piratoxin-I and/or bothropstoxin-II. Histopathology of pancreas and lungs in piratoxin-I-injected rats showed interstitial oedema in both tissues, and neutrophil infiltration with acinar cell necrosis in pancreas. In conclusion, sPLA(2)s induce AP in rats and the catalytic activity is not essential to induce the local effects in pancreas, although it appears to contribute partly to the remote lung injury.
dc.description46
dc.description921-6
dc.languageeng
dc.relationToxicon : Official Journal Of The International Society On Toxinology
dc.relationToxicon
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAmylases
dc.subjectAnalysis Of Variance
dc.subjectAnimals
dc.subjectCobra Venoms
dc.subjectCrotalid Venoms
dc.subjectGroup Ii Phospholipases A2
dc.subjectLung
dc.subjectPancreas
dc.subjectPancreatitis, Acute Necrotizing
dc.subjectPeroxidase
dc.subjectPhospholipases A
dc.subjectRats
dc.subjectReptilian Proteins
dc.titleCharacterization Of The Acute Pancreatitis Induced By Secretory Phospholipases A2 In Rats.
dc.typeArtículos de revistas


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