Effect Of Obesity On Insulin Signaling Through Jak2 In Rat Aorta.

dc.creatorGottardello Zecchin, Henrique
dc.creatorDe Souza, Claudio Teodoro
dc.creatorOliveira Prada, Patrícia
dc.creatorCampello Carvalheira, José Barreto
dc.creatorAugusto Velloso, Licio
dc.creatorAbdalla Saad, Mario José
dc.date2005-Nov
dc.date2015-11-27T13:02:30Z
dc.date2015-11-27T13:02:30Z
dc.date.accessioned2018-03-29T01:01:35Z
dc.date.available2018-03-29T01:01:35Z
dc.identifierVascular Pharmacology. v. 43, n. 5, p. 346-52, 2005-Nov.
dc.identifier1537-1891
dc.identifier10.1016/j.vph.2005.08.019
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16236556
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196452
dc.identifier16236556
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296685
dc.descriptionPathway specific resistance to insulin signaling through PI 3-kinase/Akt/eNOS associated with a normal or hyper-activated MAP kinase signaling in vascular tissues has recently been proposed as a candidate link between cardiovascular disease and insulin resistance. Growth stimulatory pathways other than ERK/MAP kinase, such as JAK/STAT have not yet been investigated in vessels of animal models of insulin resistance. Here we have examined whether insulin is able to activate JAK2/STAT pathway in rat aorta and also the regulation of this pathway in an animal model of obesity/insulin resistance. Our results demonstrate that insulin activates JAK2 tyrosine kinase activity in rat aorta in parallel with the activation of STAT3 and STAT5a/b. Moreover, it is shown that, in obese animals, JAK2/STAT and MAP kinase pathways are hyper-activated in response to insulin, which occurs in association with a reduced activation of PI 3-kinase/Akt pathway in aorta. The results of the present study suggest that, besides ERK/MAP kinase pathway, another potentially pro-atherogenic pathway, JAK2/STAT is hyper-activated in vessels in a state of insulin resistance and this phenomenon, in association with the inhibition of the PI 3-kinase/Akt pathway, may play an important role in the pathogenesis of cardiovascular diseases.
dc.description43
dc.description346-52
dc.languageeng
dc.relationVascular Pharmacology
dc.relationVascul. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAorta, Thoracic
dc.subjectDiet
dc.subjectGlucose Tolerance Test
dc.subjectImmunoprecipitation
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectJanus Kinase 2
dc.subjectMale
dc.subjectMitogen-activated Protein Kinases
dc.subjectObesity
dc.subjectProtein-tyrosine Kinases
dc.subjectProto-oncogene Proteins
dc.subjectProto-oncogene Proteins C-akt
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.titleEffect Of Obesity On Insulin Signaling Through Jak2 In Rat Aorta.
dc.typeArtículos de revistas


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