The Effects Of Restraint Stress On Nociceptive Responses Induced By Formalin Injected In Rat's Tmj.

dc.creatorGameiro, Gustavo Hauber
dc.creatorAndrade, Annicele da Silva
dc.creatorde Castro, Margaret
dc.creatorPereira, Lígia Ferrinho
dc.creatorTambeli, Cláudia Herrera
dc.creatorVeiga, Maria Cecília Ferraz de Arruda
dc.date2005-Oct
dc.date2015-11-27T13:02:30Z
dc.date2015-11-27T13:02:30Z
dc.date.accessioned2018-03-29T01:01:34Z
dc.date.available2018-03-29T01:01:34Z
dc.identifierPharmacology, Biochemistry, And Behavior. v. 82, n. 2, p. 338-44, 2005-Oct.
dc.identifier0091-3057
dc.identifier10.1016/j.pbb.2005.09.003
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16213578
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196446
dc.identifier16213578
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296679
dc.descriptionIt has been reported that stress can alter nociception from superficial tissues, such as skin and subcutaneous region. However, the influence of stress on an experimental deep nociception model is not understood. In this study, the temporomandibular joint (TMJ) formalin test was used to evaluate the effects of acute and chronic restraint stress on nociceptive responses in rats. Animals were initially submitted to one session of acute restraint stress (1 h) or exposed to chronic stress (40 days-1 h/day). Then, animals were killed immediately to collect blood for hormonal determinations by radioimmunoassay, or submitted to the TMJ formalin test to evaluate nociception. Rats submitted to acute restraint presented a performance similar to unstressed controls in the TMJ formalin test, whereas chronically stressed rats showed an increase in nociceptive responses. After 40 days of restraint, morphine was injected i.p. (1, 5 mg/kg or saline). The stressed rats displayed decreased morphine effects on nociception compared to unstressed controls. These findings suggest that repeated stress can produce hyperalgesia, which is, at least in part, due to alterations in the activity of opioid systems. This model may help elucidate the underlying neural mechanisms that mediate the effects of repeated stress on orofacial pain.
dc.description82
dc.description338-44
dc.languageeng
dc.relationPharmacology, Biochemistry, And Behavior
dc.relationPharmacol. Biochem. Behav.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnalgesics, Opioid
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectCorticosterone
dc.subjectFormaldehyde
dc.subjectInjections
dc.subjectMale
dc.subjectMorphine
dc.subjectNaloxone
dc.subjectNarcotic Antagonists
dc.subjectNociceptors
dc.subjectPain Measurement
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRestraint, Physical
dc.subjectStress, Psychological
dc.subjectTemporomandibular Joint
dc.titleThe Effects Of Restraint Stress On Nociceptive Responses Induced By Formalin Injected In Rat's Tmj.
dc.typeArtículos de revistas


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