dc.creatorde Matos, P S
dc.creatorFerreira, A P
dc.creatorde Oliveira Facuri, F
dc.creatorAssumpção, L V M
dc.creatorMetze, K
dc.creatorWard, L S
dc.date2005-Oct
dc.date2015-11-27T13:02:28Z
dc.date2015-11-27T13:02:28Z
dc.date.accessioned2018-03-29T01:01:30Z
dc.date.available2018-03-29T01:01:30Z
dc.identifierHistopathology. v. 47, n. 4, p. 391-401, 2005-Oct.
dc.identifier0309-0167
dc.identifier10.1111/j.1365-2559.2005.02221.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16178894
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196430
dc.identifier16178894
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296663
dc.descriptionTo investigate the usefulness of immunohistochemical expression and immunolocalization of a panel of thyroid malignancy markers including HBME-1, cytokeratin (CK) 19 and galectin-3. We evaluated 170 thyroid lesions including 148 neoplastic lesions [84 papillary carcinomas (PC), 38 follicular carcinomas (FC), 18 follicular adenomas, one hyalinizing trabecular tumour, five medullary carcinomas, two anaplastic carcinomas] and 22 non-neoplastic lesions (12 adenomatous nodules and 10 Hashimoto's thyroiditis). HBME-1, galectin-3 and CK 19 were expressed in 94%, 72.6%, 72.6% of PCs and in 63%, 21%, 21% of FCs. The three markers were mostly negative in all normal tissues. Although the most helpful marker in terms of sensitivity and specificity for the follicular variant of PC and for FC diagnosis was HBME-1, when we consider the differentiation between cases of follicular variant of papillary carcinoma (FVPC) and FC or adenoma, in terms of percentage of positive cells, galectin-3 and CK 19 were more relevant. HBME-1 is the most sensitive marker for thyroid malignancy but the three markers may be useful in specific cases. This panel of markers is useful to differentiate the follicular patterned lesions, with special reference to the FVPC.
dc.description47
dc.description391-401
dc.languageeng
dc.relationHistopathology
dc.relationHistopathology
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectGalectin 3
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKeratins
dc.subjectThyroid Neoplasms
dc.subjectTumor Markers, Biological
dc.titleUsefulness Of Hbme-1, Cytokeratin 19 And Galectin-3 Immunostaining In The Diagnosis Of Thyroid Malignancy.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución