Polynitrosated Polyesters: Preparation, Characterization, And Potential Use For Topical Nitric Oxide Release.

dc.creatorSeabra, Amedea B
dc.creatorda Silva, Regiane
dc.creatorde Oliveira, Marcelo G
dc.date
dc.date2015-11-27T13:02:24Z
dc.date2015-11-27T13:02:24Z
dc.date.accessioned2018-03-29T01:01:23Z
dc.date.available2018-03-29T01:01:23Z
dc.identifierBiomacromolecules. v. 6, n. 5, p. 2512-20
dc.identifier1525-7797
dc.identifier10.1021/bm050216z
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16153087
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196404
dc.identifier16153087
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296637
dc.descriptionNew nitric oxide (NO) donor macromolecules, containing multiple S-nitrosothiol (S-NO) groups covalently attached to the polymer backbone, were prepared through the polycondensation reaction of diols (ethylene glycol and poly(ethylene glycol)) with mercaptosuccinic acid, followed by the S-nitrosation of the SH groups by a gaseous NO/O2 mixture. The polynitrosated polyesters (PNPEs) obtained were characterized by IR spectroscopy and gel permeation chromatography and displayed biological activity as vasodilators, leading to local hyperaemia when applied topically on healthy skin. Kinetic measurements in either dry or aqueous conditions have shown that PNPEs can provide sustained NO release for more than 20 h at physiological temperature. Their increased viscosity at low temperatures greatly reduces the rate of NO release, allowing for their storage for more than 90 days at -20 degrees C without decomposition. These results indicate that PNPEs have potential for topical delivery of NO in biomedical applications.
dc.description6
dc.description2512-20
dc.languageeng
dc.relationBiomacromolecules
dc.relationBiomacromolecules
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Topical
dc.subjectChromatography, Gel
dc.subjectEthylene Glycol
dc.subjectHot Temperature
dc.subjectHumans
dc.subjectKinetics
dc.subjectLight
dc.subjectMacromolecular Substances
dc.subjectModels, Chemical
dc.subjectMolecular Weight
dc.subjectNitric Oxide
dc.subjectNitric Oxide Donors
dc.subjectNitrogen
dc.subjectOxygen
dc.subjectPolyesters
dc.subjectPolyethylene Glycols
dc.subjectPolymers
dc.subjectS-nitrosothiols
dc.subjectSkin
dc.subjectSpectrophotometry
dc.subjectSpectrophotometry, Infrared
dc.subjectTemperature
dc.subjectThiomalates
dc.subjectTime Factors
dc.subjectUltraviolet Rays
dc.subjectWound Healing
dc.titlePolynitrosated Polyesters: Preparation, Characterization, And Potential Use For Topical Nitric Oxide Release.
dc.typeArtículos de revistas


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