Arnold-chiari In A Fetal Rat Model Of Dysraphism.

dc.creatorWeber Guimarães Barreto, Maria
dc.creatorFerro, Marcelo M
dc.creatorGuimarães Bittencourt, Daniel
dc.creatorViolin Pereira, Luis A
dc.creatorBarini, Ricardo
dc.creatorSbragia, Lourenço
dc.date
dc.date2015-11-27T13:02:21Z
dc.date2015-11-27T13:02:21Z
dc.date.accessioned2018-03-29T01:01:17Z
dc.date.available2018-03-29T01:01:17Z
dc.identifierFetal Diagnosis And Therapy. v. 20, n. 5, p. 437-41
dc.identifier1015-3837
dc.identifier10.1159/000086827
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16113568
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196379
dc.identifier16113568
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296612
dc.descriptionDysraphism is a defect in neural tube development, leading to dysplastic growth of the spinal cord and meninges. Myelomeningocele (MM) is just one of its forms. Hydrocephalus is among the most important alterations in MM and occurs as a consequence of Arnold-Chiari malformation (AC). Experimental models have been developed in sheep, rabbits and rats to study MM physiopathology, allowing a more detailed evaluation of clinical parameters involved in this anomaly. Using the experimental model of dysraphism in fetal rats, the aim of this study was to evaluate the relevance of AC malformations, clinical parameters and grade of histological lesions. Three groups with 16 fetuses in each were compared, MM, Control and Sham, after intrauterine surgical creation of MM on day 18.5 of gestation (term = 22 days). AC was evaluated by photographic comparison of sagittal cuts of fetal heads. Clinical and histological evaluations were also made. 88% of AC (14/16) in MM fetuses were obtained, besides 100% of clinical alterations. Necrosis and erosion of the spinal cord exposed to amniotic fluid were verified in histology. The presence of AC in the dysraphism rat model was high. These results allowed the use of this model to study alterations and intrauterine evolution of MM in a fashion similar to those observed in humans.
dc.description20
dc.description437-41
dc.languageeng
dc.relationFetal Diagnosis And Therapy
dc.relationFetal. Diagn. Ther.
dc.rightsfechado
dc.rightsCopyright (c) 2005 S. Karger AG, Basel.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectArnold-chiari Malformation
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectMale
dc.subjectMeningomyelocele
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Sprague-dawley
dc.subjectSpinal Dysraphism
dc.titleArnold-chiari In A Fetal Rat Model Of Dysraphism.
dc.typeArtículos de revistas


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