Atherogenic Lipid Profile Of Brazilian Near-term Newborns.

dc.creatorPardo, I M C G
dc.creatorGeloneze, B
dc.creatorTambascia, M A
dc.creatorBarros-Filho, A A
dc.date2005-May
dc.date2015-11-27T13:02:09Z
dc.date2015-11-27T13:02:09Z
dc.date.accessioned2018-03-29T01:00:56Z
dc.date.available2018-03-29T01:00:56Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 38, n. 5, p. 755-60, 2005-May.
dc.identifier0100-879X
dc.identifier/S0100-879X2005000500013
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15917957
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196286
dc.identifier15917957
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296519
dc.descriptionCardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 +/- 8.02 vs 70.42 +/- 1.63 mg/dl, P < 0.01), due to an increase in the LDL-cholesterol fraction in the near-term group (57.76 +/- 6.39 vs 34.38 +/- 1.29 mg/dl, P < 0.001). The atherogenic indexes (total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A-I) were higher in the near-term group (P < 0.001, P < 0.001, and P < 0.05, respectively). The gestational age of the newborns was inversely correlated with total cholesterol and LDL-cholesterol, and also with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol indexes. These findings demonstrate that the lipid profile is worse in the group of near-term neonates compared with the term group. Future studies are needed to determine if this atherogenic profile in near-term neonates can affect body metabolism, increasing the risk for cardiovascular diseases in adult life.
dc.description38
dc.description755-60
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectApolipoproteins
dc.subjectBiological Markers
dc.subjectBrazil
dc.subjectCardiovascular Diseases
dc.subjectCholesterol
dc.subjectCholesterol, Hdl
dc.subjectCholesterol, Ldl
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectGestational Age
dc.subjectHumans
dc.subjectInfant, Low Birth Weight
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectRisk Factors
dc.titleAtherogenic Lipid Profile Of Brazilian Near-term Newborns.
dc.typeArtículos de revistas


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