Natural Killer Cell Activity And Anti-tumour Effects Of Dehydrocrotonin And Its Synthetic Derivatives.

dc.creatorMelo, Patricia S
dc.creatorJusto, Giselle Z
dc.creatorDurán, Nelson
dc.creatorHaun, Marcela
dc.date2004-Mar
dc.date2015-11-27T12:58:48Z
dc.date2015-11-27T12:58:48Z
dc.date.accessioned2018-03-29T01:00:26Z
dc.date.available2018-03-29T01:00:26Z
dc.identifierEuropean Journal Of Pharmacology. v. 487, n. 1-3, p. 47-54, 2004-Mar.
dc.identifier0014-2999
dc.identifier10.1016/j.ejphar.2004.01.027
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15033375
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196163
dc.identifier15033375
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296396
dc.descriptionIn this work, the anti-tumour properties of dehydrocrotonin and its derivatives were investigated in vitro and in vivo using the Ehrlich ascites tumour model. Treatment of Ehrlich ascites tumour-bearing mice with 20 mg/kg dehydrocrotonin for 4 days significantly increased survival, whereas administration of dehydrocrotonin derivatives was ineffective in affording protection. Compound IV exhibited little activity against Ehrlich tumour cells in vitro. Investigation of the effects of dehydrocrotonin treatment on total natural killer (NK) cell activity of tumour-bearing mice as a possible mechanism of dehydrocrotonin action in vivo revealed that this sesquiterpene lactone significantly improved NK cytotoxicity against YAC-1, a Moloney virus-induced mouse T-cell lymphoma of A/SN origin. As expected, tumour growth in non-treated mice markedly suppressed NK cell cytolysis. No effects on NK functional activity were observed in normal mice receiving dehydrocrotonin. In summary, only the natural compound exhibits anti-tumour efficacy and immunomodulatory actions in vivo, which may be related to its chemical structure.
dc.description487
dc.description47-54
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectCarcinoma, Ehrlich Tumor
dc.subjectCell Survival
dc.subjectCroton
dc.subjectDiterpenes, Clerodane
dc.subjectImmune System
dc.subjectKiller Cells, Natural
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectPhosphoric Monoester Hydrolases
dc.subjectSpleen
dc.subjectT-lymphocytes, Regulatory
dc.subjectTetrazolium Salts
dc.subjectThiazoles
dc.titleNatural Killer Cell Activity And Anti-tumour Effects Of Dehydrocrotonin And Its Synthetic Derivatives.
dc.typeArtículos de revistas


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